To solve the clinical transformation dilemma of lamin A/C (LMNA)-mutated dilated cardiomyopathy (LMD), we developed an LMNA-mutated primate model based on the similarity between the phenotype of primates and humans. We screened out patients with LMD and compared the clinical data of LMD with TTN-mutated and mutation-free dilated cardiomyopathy to obtain the unique phenotype. After establishment of the LMNA c.3572A >G primate model, primates were continuously observed for 48 months, and echocardiographic, electrophysiological, histologic, and transcriptional data were recorded. The LMD primate model was found to highly simulate the phenotype of clinical LMD. In addition, the LMD primate model shared a similar natural history with humans. (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
基金：
National Natural Science Fund for Distinguished Young Scholars of China [82125004]; National Key Research and Development Program of China [2021YFA0805700]; National Natural Science Foundation of China [U2102204]; Natural Science Foundation of Yunnan Province [202001BC070001, 202102AA100053]
第一作者机构：[1]Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming 650500, Yunnan, Peoples R China[2]Yunnan Key Lab Primate Biomed Res, Kunming, Yunnan, Peoples R China[3]Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming 650500, Yunnan, Peoples R China[2]Yunnan Key Lab Primate Biomed Res, Kunming, Yunnan, Peoples R China[3]Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Peoples R China[4]Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Beijing Key Lab Preclin Res & Evaluat Cardiovasc I, Anim Expt Ctr,Natl Ctr Cardiovasc Dis,Dept Cardiac, 167A Bellishi Rd, Beijing 100037, Peoples R China[5]Chinese Acad Med Sci, Shenzhen Key Lab Cardiovasc Dis, Fuwai Hosp, Shenzhen, Peoples R China[*1]Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Centre, National Centre for Cardiovascular Disease, Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Bellishi Road, Xi Chen District, Beijing 100037, China.[*2]State Key Laboratory of Primate Biomedical Research,Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China
推荐引用方式(GB/T 7714)：
Luo Xiang,Jia Hao,Wang Fang,et al.Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy[J].JACC-BASIC TO TRANSLATIONAL SCIENCE.2024,9(3):380-395.doi:10.1016/j.jacbts.2023.11.002.
APA：
Luo, Xiang,Jia, Hao,Wang, Fang,Mo, Han,Kang, Yu...&Niu, Yuyu.(2024).Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy.JACC-BASIC TO TRANSLATIONAL SCIENCE,9,(3)
MLA：
Luo, Xiang,et al."Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy".JACC-BASIC TO TRANSLATIONAL SCIENCE 9..3(2024):380-395
