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Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents

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机构： [1]College of Animal Science and Technology, Sichuan Agricultural University, Wenjiang, People’s Republic of China [2]Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Wenjiang, People’s Republic of China [3]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, People’s Republic of China [4]School of Life and Pharmaceutical Sciences, Hainan University, Haikou, People’s Republic of China [5]Reproductive Genetics Center, The First Hospital of Kunming, Kunming, People’s Republic of China

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关键词： NXT1 NXT2 Primate Murine rodent Animal model

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Translocation of RNA across the nuclear envelope relies on transport receptors. Receptor nuclear transport factor 2 (NTF2)-like export protein 1 (NXT1 [also called p15 or p15-1]) shuttles between the nucleus and cytoplasm of metazoan cells and contributes to the nuclear export of a diverse spectrum of RNAs. NXT2 (also called p15-2), a paralog of NXT1 in eutherians, also has implications for RNA nuclear export. A comprehensive description is currently lacking as to the genetic signature of these molecules. In this study, we analyzed genetic changes in the NXT1 and NXT2 genes in primates and murine rodents, including the commonly used model organisms Macaca spp., Mus musculus, and Rattus norvegicus. The results show that NXT1 has been subject to functional constraints in both phylogenetic lineages. Conversely, NXT2 exhibits discrepant patterns of genetic changes between these taxa. Murine NXT2 has evolved conservatively; by contrast, adaptive selection has frequently contributed to genetic changes in primate NXT2. The genetic discrepancy of the NXT2 orthologs leads to the suggestion that they had experienced quite different evolutionary fates potentially constituting different functional implementations in these taxa. These findings raise awareness of further study on different organisms to comprehensively understand their functional characteristics.Copyright © 2022 Elsevier GmbH. All rights reserved.

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出版当年[2022]版：

大类 | 3 区生物学

小类 | 3 区动物学

最新[2023]版：

大类 | 3 区生物学

小类 | 2 区动物学

第一作者：

第一作者机构： [1]College of Animal Science and Technology, Sichuan Agricultural University, Wenjiang, People’s Republic of China [2]Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Wenjiang, People’s Republic of China

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通讯机构： [1]College of Animal Science and Technology, Sichuan Agricultural University, Wenjiang, People’s Republic of China [2]Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Wenjiang, People’s Republic of China [5]Reproductive Genetics Center, The First Hospital of Kunming, Kunming, People’s Republic of China [*1]College of Animal Science and Technology, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, People’s Republic of China. [*2]Reproductive Genetics Center, The First Hospital of Kunming, Kunming, People’s Republic of China

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Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents

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