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The diagnostic value and clinical relevance of high frequency ultrasound and shear wave elastography in systemic sclerosis: an observational monocentric study

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机构: [1]Department of Rheumatology and Immunology, The First People’s Hospital of Yunnan Province, The afliated hospital of Kunming University of Science and Technology, Jinbi Road, No.157, Kunming 650032, Yunnan Province, China [2]Department of Rheumatology and Immunology, The Guigang People’s Hospital, The Eighth Afliated Hospital of Guangxi Medical University, Zhongshan Middle Road, No.1, Guigang 537100, Guangxi Province, China [3]Department of Ultrasound, The First People’s Hospital of Yunnan Province, The afliated hospital of Kunming University of Science and Technology, Jinbi Road, No.157, Kunming 650032, Yunnan Province, China
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关键词: Clinical relevance  Diagnosis  High frequency ultrasound  Shear wave elastography  Systemic sclerosis

摘要:
To unravel the features of skin involvement in patients with systemic sclerosis (SSc) by high frequency ultrasound (HFU) and shear wave elastography (SWE). To assess the ultrasound capabilities to distinguish SSc patients from healthy controls (HCs). We recruited a cohort of SSc patients in this cross-sectional study. HFU and SWE were used to quantify skin thickness and skin stiffness. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic capabilities of ultrasound in SSc. The correlation analysis was used to evaluate the clinical relevance of ultrasound measurements in SSc. 20 consecutive SSc patients and 20 age-, gender- and body mass index-matched HCs were included. The skin thickness and stiffness were significantly greater in SSc patients compared with HCs. Patients with high disease activity had higher skin thickness and stiffness compared with patients with low disease activity. The area under the ROC curve (AUC) of the dorsum of middle fingers assessed by HFU was 0.847 (95% CI, 0.761-0.933). The AUC of the forearms and dorsum of hands assessed by SWE were 0.909 (95% CI, 0.829-0.989) and 0.879 (95% CI, 0.807-0.951). Further, the combined HFU and SWE tests displayed the best diagnostic performance with an AUC of 0.980 (95% CI, 0.939-1.000). A significant positive correlation between the ultrasound measurements and the modified Rodnan skin score (mRSS) was observed. The application of ultrasound can assist with disease diagnosis, it is necessary to develop a standard operating protocol to help with future implementation of ultrasound in SSc.© 2024. The Author(s).

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出版当年[2025]版:
大类 | 3 区 医学
小类 | 4 区 风湿病学
最新[2025]版:
大类 | 3 区 医学
小类 | 4 区 风湿病学
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出版当年[2023]版:
Q2 RHEUMATOLOGY
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Q2 RHEUMATOLOGY

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第一作者机构: [1]Department of Rheumatology and Immunology, The First People’s Hospital of Yunnan Province, The afliated hospital of Kunming University of Science and Technology, Jinbi Road, No.157, Kunming 650032, Yunnan Province, China
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