机构：[1]Department of Ophtalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province,昆明医科大学附属第一医院[2]Department of Ultrasound, Yancheng Institute of Clinical (The First People’s Hospital of Yancheng), Xuzhou Medical University, Yancheng, Jiangsu Province, P.R. China
Aims: To assess the safety and feasibility of acoustic radiation force impulse (ARFI) elastography in the eyes of rats. Material and methods: One hundred and twenty-six SD rats were divided into 7 groups. Group 1 was the control group and Group 2 to Group 7 were investigated by ARFI elastography using increased powers of 5%, 10%, 20%, 50%, and 100% and repetitions of 5 or 10. The changes of ocular architecture structures and functions were examined by ophthalmoscopic, histopathologic, and light reflex examination, and the expression level of IL-6, IL-8, and TNF-alpha was determined in days 1, 3, and 7 after ARFI elastography, respectively. Results: A satisfactory ARFI elastography was obtained in all SD rats. The shear wave velocity (SWV) values of soft tissues behind the eyeball were significantly greater than those of the eyes (1.89 +/- 0.95 vs. 0.84 +/- 0.36 m/s, p<0.05). The SWV values of eyes and the soft tissues behind the eyeball did not differ among any groups at any time-point (p>0.05). The SD rats of each group showed good light perception, pupillary light reflex, and avoidance reaction induced by the sudden bright light from the dark environment at any time. In each group, ocular architecture structures were well preserved, and with a normal expression level of IL-6, IL-8, and TNF-alpha (p>0.05). Conclusions: Diagnostic ARFI elastography is a safe and feasible ultrasonic imaging mode and may potentially be applied for human eyes in its present form.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区核医学
最新[2023]版：
大类|4 区医学
小类|4 区声学4 区核医学
JCR分区：
出版当年[2016]版：
Q4RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2ACOUSTICSQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Department of Ophtalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province,
共同第一作者：
通讯作者：
通讯机构：[2]Department of Ultrasound, Yancheng Institute of Clinical (The First People’s Hospital of Yancheng), Xuzhou Medical University, Yancheng, Jiangsu Province, P.R. China[*1]Department of Ultrasound,Yancheng Institute of Clinical Medicine (The First People’s Hospital of Yancheng) Xuzhou Medical University 166 West Yulong Road, Yancheng 224005, Jiangsu Province, P.R. China
推荐引用方式(GB/T 7714)：
Zha Li,Chen Ke-Qi,Zheng Xiao-Zhi,et al.The safety and feasibility of diagnostic acoustic radiation force impulse elastography used for eyes. A preliminary in vivo study[J].MEDICAL ULTRASONOGRAPHY.2017,19(2):185-189.doi:10.11152/mu-996.
APA：
Zha, Li,Chen, Ke-Qi,Zheng, Xiao-Zhi&Wu, Jing.(2017).The safety and feasibility of diagnostic acoustic radiation force impulse elastography used for eyes. A preliminary in vivo study.MEDICAL ULTRASONOGRAPHY,19,(2)
MLA：
Zha, Li,et al."The safety and feasibility of diagnostic acoustic radiation force impulse elastography used for eyes. A preliminary in vivo study".MEDICAL ULTRASONOGRAPHY 19..2(2017):185-189
