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The Barthel Index predicts surgical textbook outcomes following hepatectomy for elderly patients with hepatocellular carcinoma: A multicenter cohort study

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机构: [1]First Hosp Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Changchun, Jilin, Peoples R China [2]Naval Med Univ, Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepatobiliary Surg, 225, Changhai Rd, Shanghai 200438, Peoples R China [3]Zhejiang Prov Peoples Hosp, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Zhejiang, Peoples R China [4]First Hosp Jilin Univ, Dept Clin Res, Phase Clin Trial Unit 1, Changchun, Jilin, Peoples R China [5]Liuyang Peoples Hosp, Dept Gen Surg, Liuyang, Hunan, Peoples R China [6]Nantong Univ, Dept Hepatobiliary Surg, Affiliated Hosp, Nantong, Jiangsu, Peoples R China [7]Fuyang Peoples Hosp, Dept Hepatobiliary Surg, Fuyang, Anhui, Peoples R China [8]Puer Peoples Hosp, Dept Hepatobiliary Surg, Puer, Yunnan, Peoples R China [9]Ziyang First Peoples Hosp, Dept Gen Surg, Ziyang, Sichuan, Peoples R China [10]Shandong First Med Univ, Dept Gen Surg, Affiliated Hosp 1, Jinan, Shandong, Peoples R China [11]Shandong Prov Qianfoshan Hosp, Jinan, Shandong, Peoples R China [12]Fourth Hosp Harbin, Dept Gen Surg 1, Harbin, Heilongjiang, Peoples R China [13]Harbin Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
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关键词: Hepatectomy Hepatocellular carcinoma Elderly Frailty Textbook outcomes

摘要:
Background: The burgeoning demand for hepatectomy in elderly patients with hepatocellular carcinoma (HCC) necessitates improved perioperative care. Geriatric populations frequently experience functional decline and frailty, predisposing them to adverse postoperative outcomes. The Barthel Index serves as a reliable measure for assessing functional capacity, and this study evaluates its impact on surgical textbook outcomes (TOs) in elderly HCC patients. Methods: A multicenter retrospective cohort study analyzed elderly patients (>70 years) following hepatectomy for HCC between 2013 and 2021. Utilizing a Barthel Index cut-off value of 85, patients were divided into two groups: with and without preoperative functional decline and frailty. The primary outcome was the rate of TO, encompassing seven criteria. TO rates were compared between groups, and multivariate logistic regression analyses identified independent risks for achieving TOs. Results: Of 497 elderly patients, 157 (31.6 %) exhibited preoperative functional decline and frailty (Barthel Index score <85). The overall TO rate was 58.6 %. Patients with preoperative Barthel Index score <85 had significantly lower TO rates compared to patients with score >85 (29.3 % vs. 72.1 %, P < 0.001). Multivariate analysis revealed preoperative Barthel Index score <85 as an independent risk for achieving TO (odds ratio 3.413, 95 % confidence interval 1.879-6.198, P < 0.001). Comparable results were observed in the subgroups of patients undergoing open and laparoscopic hepatectomy. Conclusion: Preoperative Barthel Index-based assessment of functional decline and frailty significantly predicts TOs following hepatectomy in elderly HCC patients, enabling identification of high-risk patients and informing preoperative management and postoperative care within geriatric oncology.

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大类 | 3 区 医学
小类 | 3 区 外科
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Q1 SURGERY
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Q1 SURGERY

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第一作者机构: [1]First Hosp Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Changchun, Jilin, Peoples R China [2]Naval Med Univ, Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepatobiliary Surg, 225, Changhai Rd, Shanghai 200438, Peoples R China
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通讯机构: [1]First Hosp Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Changchun, Jilin, Peoples R China [2]Naval Med Univ, Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepatobiliary Surg, 225, Changhai Rd, Shanghai 200438, Peoples R China
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