机构：[1]Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.华中科技大学同济医学院附属同济医院[2]Department of Nuclear Medicine, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, China.医技片核医学科云南省第一人民医院[3]Department of Anatomy, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
T cells are indispensable for the therapeutic efficacy of cancer immunotherapies, including immune checkpoint blockade. However, prolonged antigen exposure also drives T cells into exhaustion, which is characterized by upregulated inhibitory molecules, impaired effector functions, reduced cytotoxicity, altered metabolism, etc. Noninvasive monitoring of T cell exhaustion allows a timely identification of cancer patients that are most likely to benefit from immunotherapies. In this Review, we briefly explain the biological cascades underlying the modulation of inhibitory molecules, present a concise update on the nuclear molecular imaging tracers of T cell exhaustion, and then discuss the potential opportunities for future development.
基金：
This work was supported by the National Natural Science
Foundation of China (Nos. 82272041, 91959119, 81873903).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|2 区医学
小类|2 区药学3 区医学：研究与实验
最新[2025]版：
大类|2 区医学
小类|2 区药学3 区医学：研究与实验
JCR分区：
出版当年[2023]版：
Q1PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
通讯作者：
通讯机构：[1]Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.[3]Department of Anatomy, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
推荐引用方式(GB/T 7714)：
Zhou Huimin,Bao Guangfa,Zhao Jun,et al.Nuclear Molecular Imaging for Evaluating T Cell Exhaustion[J].MOLECULAR PHARMACEUTICS.2024,22(1):103-112.doi:10.1021/acs.molpharmaceut.4c00970.
APA：
Zhou Huimin,Bao Guangfa,Zhao Jun&Zhu Xiaohua.(2024).Nuclear Molecular Imaging for Evaluating T Cell Exhaustion.MOLECULAR PHARMACEUTICS,22,(1)
MLA：
Zhou Huimin,et al."Nuclear Molecular Imaging for Evaluating T Cell Exhaustion".MOLECULAR PHARMACEUTICS 22..1(2024):103-112
