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Dysregulation of G6PD by HPV E6 exacerbates cervical cancer by activating the STAT3/PLOD2 pathway

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资源类型：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhang Jie[1,2] * ; Dong Wei[1,2] * ; Yang Qin[1,2] * ; Liu Li-Na[3,4] * ; Cai Xi-Lun[1,2] ; Wang Dan[3] ; Yan Guo-Ji[3] ; Xiyang Yan-Bin[3] ; Hu Tao[5] ; Zhang Jie[1,6,7] ;
机构： [1]Department of Medical Genetics, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases, National Health Commission Key Laboratory of Preconception Health Birth in Western China, the First People’s Hospital of Yunnan Province, Kunming 650100, P.R. China [2]Department of Obstetrics and Gynecology, The First People's Hospital of Yunnan Province, Kunming 650100, China [3]Institute of Neuroscience, Kunming Medical University, Kunming, 650500, P.R. China [4]Department of Pathology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, 230001, P.R. China [5]Department of Laboratory Medicine, The Third People’s Hospital of Yunnan Province, Kunming 650200, China [6]Medical school, Kunming University of Science and Technology, Kunming 650100, China [7]Department of hematology, Yunnan Provincial Clinical Medical Center for Blood Diseases and Thrombosis Prevention and Treatment, the First People’s Hospital of Yunnan Province, Kunming 650100, China.
出处：
DOI： 10.1093/carcin/bgaf005
ISSN：

关键词： High-risk human papillomavirus 16 Glucose-6-phosphate dehydrogenase Signal transducer and activator of transcription 3 Procollagen-lysine 2-oxoglutarate 5-dioxygenase

摘要：
High-risk human papillomavirus (HPV) infection is strongly linked to the initiation and progression of cervical cancer, yet the precise molecular mechanisms involved remain partially understood. This investigation examined differential protein expression profiles in various cohorts, including healthy controls and HPV-positive cervical cancer patients with different expression levels of glucose-6-phosphate dehydrogenase (G6PD), shedding light on the dysregulation of oncogenic proteins by HPV. Proteomic analysis of cervical tissues revealed specific protein signatures, indicating significant upregulation of HPV E6, G6PD, STAT3, phosphorylated STAT3, and procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2) in HPV-infected cervical cancer tissues and cell lines. Functional experiments, involving the manipulation of G6PD and STAT3 activities in cervical cancer cells with HPV E6 modulation, demonstrated that dysregulated G6PD enhanced cell proliferation, migration, and invasion while suppressing apoptosis, primarily through the STAT3/PLOD2 pathway. Integrating these findings with the existing literature underscores the role of G6PD as an oncogene, potentially under STAT3 regulation, and highlights the role of PLOD2 as a pivotal factor in cervical cancer progression. This study also proposed a mechanism in which HPV E6-induced dysregulation of G6PD activates the STAT3-PLOD2 axis to promote cervical cancer progression. Understanding the intricate interplay between HPV E6, G6PD, STAT3, and PLOD2 offers valuable insights into the molecular landscape of cervical cancer. These findings may pave the way for targeted therapeutic approaches aimed at disrupting this axis to mitigate the progression of cervical cancer.© The Author(s) 2025. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

基金：
This study was supported by Ten Thousand People Planning Commission of Yunnan Province (KH-SWR-MY-2020-011), Young and Middle-Aged Academic Leaders Planning Commission of Yunnan Province (202105AC160034), and Basic Research Project-Key Projects of Yunnan Province (202301AS070007).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Medical Genetics, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases, National Health Commission Key Laboratory of Preconception Health Birth in Western China, the First People’s Hospital of Yunnan Province, Kunming 650100, P.R. China [2]Department of Obstetrics and Gynecology, The First People's Hospital of Yunnan Province, Kunming 650100, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Medical Genetics, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases, National Health Commission Key Laboratory of Preconception Health Birth in Western China, the First People’s Hospital of Yunnan Province, Kunming 650100, P.R. China [6]Medical school, Kunming University of Science and Technology, Kunming 650100, China [7]Department of hematology, Yunnan Provincial Clinical Medical Center for Blood Diseases and Thrombosis Prevention and Treatment, the First People’s Hospital of Yunnan Province, Kunming 650100, China.
推荐引用方式(GB/T 7714)：
Zhang Jie,Dong Wei,Yang Qin,et al.Dysregulation of G6PD by HPV E6 exacerbates cervical cancer by activating the STAT3/PLOD2 pathway[J].Carcinogenesis.2025,doi:10.1093/carcin/bgaf005.
APA：
Zhang Jie,Dong Wei,Yang Qin,Liu Li-Na,Cai Xi-Lun...&Zhang Jie.(2025).Dysregulation of G6PD by HPV E6 exacerbates cervical cancer by activating the STAT3/PLOD2 pathway.Carcinogenesis,,
MLA：
Zhang Jie,et al."Dysregulation of G6PD by HPV E6 exacerbates cervical cancer by activating the STAT3/PLOD2 pathway".Carcinogenesis .(2025)

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