Eukaryotic somatic cells undergo continuous telomere shortening because of end-replication problems. Approximately 10%similar to 15% of human cancers rely on alternative lengthening of telomeres (ALT) to overcome telomere shortening. ALT cells are characterized by persistent telomere DNA replication stress and rely on recombination-based DNA repair pathways for telomere elongation. The Bloom syndrome (BLM) helicase is a member of the RecQ family, which has been implicated as a key regulator of the ALT mechanism as it is required for either telomere length maintenance or telomere clustering in ALT-associated promyelocytic leukemia bodies (APBs). Here, we summarize recent evidence detailing the role of BLM in the activation and maintenance of ALT. We propose that the role of BLM-dependent recombination and its interacting proteins remains a crucial question for future research in dissecting the molecular mechanisms of ALT.
基金:
Yunnan Fundamental Research Project [202101AY070001-235, 202201AS070074]; Yunnan "Xing Dian Ying Cai" project [202201AS070074, YNWR-QNBJ-2019-240]; Joint Foundation of Kunming University of Science and Technology [KUST-KH2022007Y]
第一作者机构:[1]Kunming Univ Sci & Technol, Med Sch, Lab Mol Genet Aging & Tumor, 727 Jing Ming Nan Rd, Kunming 650500, Yunnan, Peoples R China[2]Kunming Univ Sci & Technol,Peoples Hosp Yunnan Prov 1,Affiliated Hosp,Dept Neurosurg,157 Jinbi Rd,Kunming 650032,Yunnan,Peoples R China
通讯作者:
通讯机构:[1]Kunming Univ Sci & Technol, Med Sch, Lab Mol Genet Aging & Tumor, 727 Jing Ming Nan Rd, Kunming 650500, Yunnan, Peoples R China[2]Kunming Univ Sci & Technol,Peoples Hosp Yunnan Prov 1,Affiliated Hosp,Dept Neurosurg,157 Jinbi Rd,Kunming 650032,Yunnan,Peoples R China
推荐引用方式(GB/T 7714):
Chang Shun,Tan Jiang,Bao Ren,et al.Multiple functions of the ALT favorite helicase, BLM[J].CELL AND BIOSCIENCE.2025,15(1):doi:10.1186/s13578-025-01372-3.
APA:
Chang, Shun,Tan, Jiang,Bao, Ren,Zhang, Yanduo,Tong, Jinkai...&Jia, Shuting.(2025).Multiple functions of the ALT favorite helicase, BLM.CELL AND BIOSCIENCE,15,(1)
MLA:
Chang, Shun,et al."Multiple functions of the ALT favorite helicase, BLM".CELL AND BIOSCIENCE 15..1(2025)