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Multiple functions of the ALT favorite helicase, BLM

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机构: [1]Kunming Univ Sci & Technol, Med Sch, Lab Mol Genet Aging & Tumor, 727 Jing Ming Nan Rd, Kunming 650500, Yunnan, Peoples R China [2]Kunming Univ Sci & Technol,Peoples Hosp Yunnan Prov 1,Affiliated Hosp,Dept Neurosurg,157 Jinbi Rd,Kunming 650032,Yunnan,Peoples R China
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关键词: BLM Alternative lengthening of telomeres (ALT) Telomere Replication stress

摘要:
Eukaryotic somatic cells undergo continuous telomere shortening because of end-replication problems. Approximately 10%similar to 15% of human cancers rely on alternative lengthening of telomeres (ALT) to overcome telomere shortening. ALT cells are characterized by persistent telomere DNA replication stress and rely on recombination-based DNA repair pathways for telomere elongation. The Bloom syndrome (BLM) helicase is a member of the RecQ family, which has been implicated as a key regulator of the ALT mechanism as it is required for either telomere length maintenance or telomere clustering in ALT-associated promyelocytic leukemia bodies (APBs). Here, we summarize recent evidence detailing the role of BLM in the activation and maintenance of ALT. We propose that the role of BLM-dependent recombination and its interacting proteins remains a crucial question for future research in dissecting the molecular mechanisms of ALT.

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大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学
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Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
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Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

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第一作者机构: [1]Kunming Univ Sci & Technol, Med Sch, Lab Mol Genet Aging & Tumor, 727 Jing Ming Nan Rd, Kunming 650500, Yunnan, Peoples R China [2]Kunming Univ Sci & Technol,Peoples Hosp Yunnan Prov 1,Affiliated Hosp,Dept Neurosurg,157 Jinbi Rd,Kunming 650032,Yunnan,Peoples R China
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通讯机构: [1]Kunming Univ Sci & Technol, Med Sch, Lab Mol Genet Aging & Tumor, 727 Jing Ming Nan Rd, Kunming 650500, Yunnan, Peoples R China [2]Kunming Univ Sci & Technol,Peoples Hosp Yunnan Prov 1,Affiliated Hosp,Dept Neurosurg,157 Jinbi Rd,Kunming 650032,Yunnan,Peoples R China
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