The structural characteristics and osteoinduction of porous hydroxyapatite (HA) are different from those of natural bone which makes it unsatisfactory for bone repair. ZnO NPs can enhance the osteogenic function via synergistic angiogenesis and osteogenesis, and have good antibacterial ability. Tailoring the pore characteristics of porous HA can enhance its biocompatibility and degradability. In this study, porous ZnO/HA scaffolds were fabricated via spark plasma sintering (SPS) without any binder. By controlling the porosity of porous ZnO/HA scaffolds, the pore characteristics, mechanical properties and pore connectivity can be effectively regulated. With the increase of porosity of scaffold, the number of large pores and inter-pore connectivity also increases. However, the mechanical properties of the scaffold significantly decrease. The increase of porosity also accelerated the degradation of the scaffolds and the release of Zn2+. In vitro assays confirmed good cytocompatibility of the porous ZnO/HA scaffolds. The ZnO NPs released during degradation exhibited significant antibacterial activity. In vivo implantation results demonstrated that Zn2+ release effectively reduced inflammatory markers without inducing liver or kidney toxicity. The ZnO/HA scaffolds exhibited good biocompatibility, and the rabbit radius defect model confirmed their bone repair capability. Zn2+ released in vivo promoted both angiogenesis and osteogenesis, facilitating new tissue formation within the porous HA scaffolds. This study provides a porous ZnO/ HA scaffold with osseointegration potential, antibacterial activity, and bioresorbability.