机构：[1]Department of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical University, Yunnan, China昆明医科大学附属第一医院[2]Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Yunnan, China昆明医科大学附属第一医院
Background Chemotherapy is the standard treatment for non-small cell lung cancer (NSCLC). However, chemoresistance frequently occurs, making the treatment of NSCLC more difficult. Method We combined clinical and experimental studies to establish the role of microRNA (miR)-34c in NSCLC metastasis and chemoresistance. Results MiR-34c expression was significantly decreased in patients with NSCLC who showed a poor chemoresponse and metastasis. Overexpression of miR-34c sensitized NSCLC cells to paclitaxel and cisplatin both in vitro and in vivo. Furthermore, we found that NOTCH1 was target of miR-34c in NSCLC cells and played a key role in the effects of miR-34c on NSCLC. Conclusion NSCLC metastasis and chemoresistance are suppressed though the miR-34c/NOTCH1 axis. MiR-34c has important implications in the development of therapeutic strategies for metastasis and chemoresistance in NSCLC.
基金：
This study was supported by the National
Natural Science Foundation of China
(81060010).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2019]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical University, Yunnan, China
通讯作者：
通讯机构：[2]Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Yunnan, China[*1]Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming City, Yunnan Province 650032, China.
推荐引用方式(GB/T 7714)：
Lin-zhu Yang,Chang-cheng Lei,Yun-ping Zhao,et al.MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2020,48(3):doi:10.1177/0300060520904847.
APA：
Lin-zhu Yang,Chang-cheng Lei,Yun-ping Zhao,Hong-wen Sun,Qing-he Yu...&Xi Zhan.(2020).MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48,(3)
MLA：
Lin-zhu Yang,et al."MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48..3(2020)
