机构：[1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang RD, Kunming 650032, Kunming, Yunnan, China昆明医科大学附属第一医院
A single nucleotide polymorphism (SNP) rs12415800 of the silent mating type information regulation 2 homolog
1 gene (SIRT1) has shown a genome-wide significant association with major depression disorder (MDD) in a
recent GWAS using a large sample. Subsequent studies of SIRT1’s biological functions were supportive of a
possible role in the pathophysiology of MDD. However, SIRT1-mediated physiopathology of MDD may be brain
region specific. In the present study, we investigated the impact of SIRT1 rs12415800 genotypes on gray matter
volumes (GMV) among different brain regions in both MDD patients and healthy controls. The rs12415800 was
genotyped in 170 patients with first-episode medication-naïve MDD (cases) and 170 healthy controls. Magnetic
resonance imaging was conducted and the voxel-based morphometry (VBM) approach was employed to analyze
obtained images. When compared with the cases carrying GG genotype, the cases carrying GA or AA genotypes
(A for risk allele) showed decreased GMV in right precuneus, left cuneus/precuneus, and right frontal superior.
In contrast, the rs12415800-associated GMV abnormalities were not observed in controls. The SIRT1-
rs12415800 polymorphism may be associated with the changes of GMV in MDD patients.
基金：
Founding of Yunnan Provincial Health Science and Technology Plan [2016NS028, 2017NS027, 2018NS0109]
第一作者机构：[1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang RD, Kunming 650032, Kunming, Yunnan, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Dai Nan,Cheng Yuqi,Shen Zonglin,et al.Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first -episode medication -na?ve major depression[J].PSYCHIATRY RESEARCH-NEUROIMAGING.2020,301:doi:10.1016/j.pscychresns.2020.111101.
APA：
Dai Nan,Cheng Yuqi,Shen Zonglin,Dong Chenglong,Li Na...&Xu Xiufeng.(2020).Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first -episode medication -na?ve major depression.PSYCHIATRY RESEARCH-NEUROIMAGING,301,
MLA：
Dai Nan,et al."Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first -episode medication -na?ve major depression".PSYCHIATRY RESEARCH-NEUROIMAGING 301.(2020)
