机构：[1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People’s Hospital of Yunnan, Kunming, Yunnan, China[2]Department of Pharmacy, Yan’An Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China[3]First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China昆明医科大学附属第一医院
Autophagy is an important mechanism for cellular self-digestion and basal homeostasis. This gene- and modulator-regulated pathway is conserved in cells. Recently, several studies have shown that autophagic dysfunction is associated with pulmonary hypertension (PH). However, the relationship between autophagy and PH remains controversial. In this review, we mainly introduce the effects of autophagy-related genes and some regulatory molecules on PH and the relationship between autophagy and PH under the conditions of hypoxia, monocrotaline injection, thromboembolic stress, oxidative stress, and other drugs and toxins. The effects of other autophagy-related drugs, such as chloroquine, 3-methyladenine, rapamycin, and other potential therapeutic drugs and targets, in PH are also described.
基金：
“Special and Joint Program” of Yunnan
Provincial Science and Technology
Department and Kunming Medical University,
Grant/Award Number: 2018FE001(‐2‐6) and
2017FE467(‐094); National Natural Science
Foundation of China, Grant/Award Number:
81560694 and 81760015; Young Academic
and Technical Leaders of Yunnan Province,
Grant/Award Number: 2017HB053; Yunnan
health training project of high level talents,
Grant/Award Number: No. D‐201627
第一作者机构：[1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People’s Hospital of Yunnan, Kunming, Yunnan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People’s Hospital of Yunnan, Kunming, Yunnan, China[3]First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China[*1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People’s Hospital of Yunnan Province, No. 176, Qingnian Road, Kunming, 650021 Yunnan, China.[*2]First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032 Yunnan, China.
推荐引用方式(GB/T 7714)：
Chun‐Fang Zhang,Fang‐Yun Zhao,Shuang‐Lan Xu,et al.Autophagy in pulmonary hypertension: Emerging roles and therapeutic implications[J].JOURNAL OF CELLULAR PHYSIOLOGY.2019,234(10):16755-16767.doi:10.1002/jcp.28531.
APA：
Chun‐Fang Zhang,Fang‐Yun Zhao,Shuang‐Lan Xu,Jie Liu,Xi‐Qian Xing&Jiao Yang.(2019).Autophagy in pulmonary hypertension: Emerging roles and therapeutic implications.JOURNAL OF CELLULAR PHYSIOLOGY,234,(10)
MLA：
Chun‐Fang Zhang,et al."Autophagy in pulmonary hypertension: Emerging roles and therapeutic implications".JOURNAL OF CELLULAR PHYSIOLOGY 234..10(2019):16755-16767
