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Regulation of circular RNAs act as ceRNA in a hypoxic pulmonary hypertension rat model.

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机构： [1]Department of Respiratory Medicine, The Affiliated Hospital of Yunnan University, The Second People’s Hospital of Yunnan Province, Kunming 650021, Yunnan, China [2]Department of Dermatology, The People’s Hospital of Yuxi City, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi 653100, Yunan, China [3]Department of Pharmacy, Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan, China [4]First Department of Respiratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China

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关键词： Hypoxic pulmonary hypertension Circular RNA microRNA Competitive endogenous RNA RNA-Seq Bioinformatics analysis

摘要：

To explore potential critical genes and identify circular RNAs (circRNAs) that act as the competitive endogenous RNA (ceRNA) in a hypoxic pulmonary hypertension (HPH) rat model. Constructed rat model, and a bioinformatics method was used to analyse differentially expressed (DE) genes and construct a circRNA-miRNA-mRNA ceRNA regulatory network. Then, qRT-PCR was used to verify. The significant DEcircRNAs/DEmiRNAs/DEmRNAs was showed, and a ceRNA network with 8 DEcircRNAs, 9 DEmiRNAs and 46 DEmRNAs were constructed. The functional enrichment suggested the inflammatory response, NF-κB signalling, MAPK cascade and Toll-like receptor were associated with HPH. Further assessment confirmed that circ_002723, circ_008021, circ_016925 and circ_020581 could have a potential ceRNA mechanism by sponging miR-23a or miR-21 to control downstream target gene and be involved in the pathophysiology of HPH. The RT-qPCR validation results were consistent with the RNA-Seq results. This study revealed potentially important genes, pathways and ceRNA regulatory networks in HPH. Copyright © 2020. Published by Elsevier Inc.

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出版当年[2021]版：

大类 | 2 区生物

小类 | 2 区生物工程与应用微生物 2 区遗传学

最新[2023]版：

大类 | 2 区生物学

小类 | 2 区生物工程与应用微生物 2 区遗传学

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出版当年[2020]版：

Q1 GENETICS & HEREDITY Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

最新[2023]版：

Q2 GENETICS & HEREDITY Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

影响因子： 3.4 最新[2023版] 3.5 最新五年平均 5.736 出版当年[2020版] 4.939 出版当年五年平均 6.205 出版前一年[2019版] 4.31 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Respiratory Medicine, The Affiliated Hospital of Yunnan University, The Second People’s Hospital of Yunnan Province, Kunming 650021, Yunnan, China

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通讯作者：

通讯机构： [1]Department of Respiratory Medicine, The Affiliated Hospital of Yunnan University, The Second People’s Hospital of Yunnan Province, Kunming 650021, Yunnan, China [4]First Department of Respiratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China [*1]Department of Respiratory Medicine, The Affiliated Hospital of Yunnan University, The Second People’s Hospital of Yunnan Province, No. 176, Qingnian Road, Kunming 650021, Yunnan, China. [*2]Department of Respiratory Medicine, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming 650032, Yunnan, China.

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Regulation of circular RNAs act as ceRNA in a hypoxic pulmonary hypertension rat model.

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