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Uncovering novel landscape of cardiovascular diseases and therapeutic targets for cardioprotection via long noncoding RNA-miRNA-mRNA axes

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收录情况： ◇ SCIE

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机构： [1]Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, PR China [2]Department of Anesthesiology, Yan’an Hospital of Kunming City, Kunming Medical University, Kunming, Yunnan Province 650051, PR China

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关键词： apoptosis atherosclerosis autophagy ceRNA endothelial cells necrosis

摘要：

Protein coding sequences account for around 3% of the human genome, the rest are noncoding RNA (ncRNA) including long ncRNA (lncRNA) and miRNA. Accumulating evidence indicates that lncRNAs and miRNAs are candidate biomarkers for diagnosis, prognosis and therapy of cardiovascular diseases. The lncRNAs act as sponge-like effects on numerous miRNAs, subsequently regulating miRNAs and their targets, mRNA functions. The role of lncRNA-miRNA-mRNA axis in pathogenesis of cardiovascular diseases has been recently reported and highlighted. Herein, this review discusses emerging roles of lncRNA-miRNA-mRNA axis in cardiovascular pathophysiology and regulation, with a novel focus on cardioprotective network activities of the two subgroup ncRNAs.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 2 区遗传学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区遗传学

JCR分区：

出版当年[2017]版：

Q1 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 3 最新[2023版] 3.4 最新五年平均 4.979 出版当年[2017版] 4.494 出版当年五年平均 4.541 出版前一年[2016版] 4.404 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, PR China [2]Department of Anesthesiology, Yan’an Hospital of Kunming City, Kunming Medical University, Kunming, Yunnan Province 650051, PR China

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