详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China

59| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China [2]Yuxi City Center for Disease Control and Prevention, Yuxi, Yunnan 653100, China [3]Wenshan Institute of Dermatology, Wenshan, Yunnan 663000, China [4]Department of Dermatology, the First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, 650032, China [5]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650201, China

出处：

DOI：

ISSN：

关键词： Leprosy MAVS MITA MFN2 SNP Susceptibility

摘要：

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae), which has massive genomic decay and dependence on host metabolism. Accumulating evidence showed a crucial role of mitochondria inmetabolism and innate immunity. We hypothesized that the mitochondrial-related antimicrobial/antiviral immune genes MAVS (mitochondrial antiviral signaling protein), MITA (mediator of IRF3 activation) and MFN2 (mitofusin 2) would confer a risk to leprosy. In this study, we performed a case-control study to analyze 11 tag and/or non-synonymous SNPs of the MAVS, MITA and MFN2 genes in 527 leprosy patients and 583 healthy individuals, and directly sequenced the three genes in 80 leprosy patients with a family history from Yunnan, Southwest China. We found no association between these SNPs and leprosy (including its subtypes) based on the frequencies of alleles, genotypes and haplotypes between the cases and controls. There was also no enrichment of potential pathogenic variants of the three genes in leprosy patients. Our results suggested that genetic variants of the MAVS, MITA and MFN2 genes might not affect the susceptibility to leprosy. (C) 2016 Elsevier B.V. All rights reserved.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2016]版：

大类 | 3 区医学

小类 | 3 区传染病学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区传染病学

JCR分区：

出版当年[2015]版：

Q2 INFECTIOUS DISEASES

最新[2023]版：

Q3 INFECTIOUS DISEASES

影响因子： 2.6 最新[2023版] 2.6 最新五年平均 2.591 出版当年[2015版] 2.846 出版当年五年平均 3.015 出版前一年[2014版] 2.885 出版后一年[2016版]

第一作者：

第一作者机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China

通讯作者：

通讯机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China [5]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650201, China [*1]Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China [2]Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing [3]Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile [4]Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy [5]Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile (vol 82, pg 18, 2016) [6]ALOX5、ALOX5AP基因多态性与髓系白血病易感性的关系 [7]Correlation between single nucleotide polymorphisms inCXCR4microRNA binding site and the susceptibility to knee osteoarthritis in Han Chinese population [8]噪声性耳聋相关基因SNP的人群遗传相关研究进展 [9]ALOX5、ALOX5AP基因多态性与髓系白血病易感性的关系 [10]Nested PCR and the TaqMan SNP Genotyping Assay enhanced the sensitivity of drug resistance testing of Mycobacterium leprae using clinical specimens of leprosy patients(Open Access)