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A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China

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作者：
Xixuan Lu[2,6] * ; Xiaoguang Shi[1,2] * ; Yanbo Li[8] * ; Haiyi Chi[9] * ; Eryuan Liao[10] * ; Chao Liu[11] * ; Libin Liu[12] * ; Yongze Li[1,2] ; Di Teng[1,2] ; Xiaochun Teng[1,2] ; Jianming Ba[3] ; Bing Chen[4] ; Jianling Du[5] ; Lanjie He[6] ; Xiaoyang Lai[7] ; Guijun Qin[13] ; Yingfen Qin[14] ; Huibiao Quan[15] ; Bingyin Shi[16] ; Hui Sun[17] ; Xulei Tang[18] ; Nanwei Tong[19] ; Guixia Wang[20] ; Jin‑an Zhang[21] ; Youmin Wang[22] ; Yuanming Xue[23] ; Li Yan[24] ; Jing Yang[25] ; Lihui Yang[26] ; Yongli Yao[27] ; Zhen Ye[28] ; Qiao Zhang[29] ; Lihui Zhang[30] ; Jun Zhu[31] ; Mei Zhu[32] ; Zhongyan Shan[1,2] ; Weiping Teng[2] ;
机构： [1]Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, Shenyang 110001, Liaoning, People’s Republic of China [2]The Institute of Endocrinology, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, Shenyang 110001, Liaoning, People’s Republic of China [3]Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China [4]Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, People’s Republic of China [5]Department of Endocrinology, The First Afliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, People’s Republic of China [6]Present Address: Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, Ningxia Medical University General Hospital, Yinchuan 750004, Ningxia, People’s Republic of China [7]Department of Endocrinology and Metabolism, The Second Afliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China [8]Department of Endocrinology, The First Afliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, People’s Republic of China [9]Department of Endocrinology, Hohhot First Hospital, Hohhot 010000, Inner Mongolia, People’s Republic of China [10]Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, People’s Republic of China [11]Research Center of Endocrine and Metabolic Diseases, Afliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, People’s Republic of China [12]Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, People’s Republic of China [13]Division of Endocrinology, Department of Internal Medicine, The First Afliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan, People’s Republic of China [14]Department of Endocrine, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of China [15]Department of Endocrinology, Hainan General Hospital, Haikou 570311, Hainan, People’s Republic of China [16]Department of Endocrinology, The First Afliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shanxi, People’s Republic of China [17]Department of Endocrinology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, Hubei, People’s Republic of China [18]Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, People’s Republic of China [19]State Key Laboratory of Biotherapy, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China [20]Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, Jilin, People’s Republic of China [21]Department of Endocrinology, Shanghai University of Medicine and Health Science Afliated Zhoupu Hospital, Shanghai 201318, People’s Republic of China [22]Department of Endocrinology, The First Hospital of An Hui Medical University, Hefei 230000, Anhui, People’s Republic of China [23]Department of Endocrinology, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, People’s Republic of China [24]Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, People’s Republic of China [25]Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, People’s Republic of China [26]Department of Endocrinology and Metabolism, People’s Hospital of Tibet Autonomous Region, Lhasa 850000, Tibet, People’s Republic of China [27]Department of Endocrinology, Qinghai Provincial People’s Hospital, Xining 810000, Qinghai, People’s Republic of China [28]Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, People’s Republic of China [29]Department of Endocrinology and Metabolism, Afliated Hospital of Guiyang Medical University, Guiyang 550004, Guizhou, People’s Republic of China [30]Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, People’s Republic of China [31]Department of Endocrinology, The First Afliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, People’s Republic of China [32]Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, People’s Republic of China
出处：
DOI： 10.1007/s00394-020-02199-z
ISSN：

关键词： Gout Hyperuricemia Iodine Prevalence Urinary iodine concentration

摘要：
Background and aims: Iodine is one of the most important trace elements in the human body. It is not only the main component of thyroid hormones but also has extrathyroid biological functions. To date, there have been no large-scale epidemiological studies on the relationship between hyperuricemia and iodine intake, although both are closely related to health. A population-based epidemiological survey in China offers such an opportunity. Methods: This population-based cross-sectional study recruited 75,653 adults aged ≥ 18 years from 2015 to 2017 with a randomized, multistage, stratified sampling strategy. Serum uric acid levels and urinary iodine concentrations (UICs) were measured. Results: Stratified by UIC, the prevalence of hyperuricemia was 17.8%, 18.8%, 16.0% and 13.7% in the UIC < 100, 100–199, 200–299, and ≥ 300 μg/L groups, respectively; the prevalence of gout was 4.0%, 3.4%, 2.4% and 1.7%, respectively. The prevalence of gout decreased significantly as the UIC increased. The prevalence of hyperuricemia and gout were markedly higher in postmenopausal females than in the premenopausal population (hyperuricemia: 15.9% vs. 8.3%, X2 = 520.072, p < 0.001; gout: 3.6% vs. 1.3%, X2 = 219.889, p < 0.001), and the prevalence decreased as the UIC increased. Subjects in the more than adequate and excessive iodine groups had lower likelihoods of having hyperuricemia [aOR = 0.81 (95% CI 0.77–0.85), aOR = 0.68 (95% CI 0.64–0.72)] and lower odds of having gout than subjects in the adequate iodine (AI) group [aOR = 0.77 (95% CI 0.68–0.86), aOR = 0.59 (95% CI 0.51–0.68)]. Conclusions: UIC was inversely associated with the occurrence of hyperuricemia and gout. More in-depth research and prospective studies are needed to explore the molecular mechanisms and confirm the observed association. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.

基金：
This work was supported by the Research Fund for Public Welfare from the National Health and Family Planning Commission of China (Grant No. 201402005).
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外文
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出版当年[2020]版：
大类 | 2 区 医学
小类 | 2 区 营养学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 营养学
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出版当年[2019]版：
Q1 NUTRITION & DIETETICS
最新[2023]版：
Q2 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [2]The Institute of Endocrinology, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, Shenyang 110001, Liaoning, People’s Republic of China [6]Present Address: Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, Ningxia Medical University General Hospital, Yinchuan 750004, Ningxia, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, Shenyang 110001, Liaoning, People’s Republic of China [2]The Institute of Endocrinology, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, Shenyang 110001, Liaoning, People’s Republic of China
推荐引用方式(GB/T 7714)：
Xixuan Lu,Xiaoguang Shi,Yanbo Li,et al.A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China[J].EUROPEAN JOURNAL OF NUTRITION.2020,59(8):3659-3668.doi:10.1007/s00394-020-02199-z.
APA：
Xixuan Lu,Xiaoguang Shi,Yanbo Li,Haiyi Chi,Eryuan Liao...&Weiping Teng.(2020).A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China.EUROPEAN JOURNAL OF NUTRITION,59,(8)
MLA：
Xixuan Lu,et al."A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China".EUROPEAN JOURNAL OF NUTRITION 59..8(2020):3659-3668

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