机构：[1]Department of Endocrinology and Metabolism and the Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China[2]Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, P.R. China[3]Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China[4]Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China大连医科大学附属第一医院[5]Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China[6]Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China[7]Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China[8]Department of Endocrinology, Hohhot First Hospital, Hohhot, Inner Mongolia 010000, P.R. China[9]Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China[10]Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China[11]Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China[12]Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China[13]Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China[14]Department of Endocrinology, Hainan General Hospital, Haikou, Hainan 570311, P.R. China[15]Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shannxi 710061, P.R. China[16]Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China华中科技大学同济医学院附属协和医院[17]Department of Endocrinology, the First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China[18]Department of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China四川大学华西医院[19]Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China[20]Department of Endocrinology, Shanghai University of Medicine & Health Science Affiliated Zhoupu Hosipital, Shanghai 201318, P.R. China[21]Department of Endocrinology, The First Hospital of An Hui Medical University, Hefei, Anhui 230000, P.R. China[22]Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China内科片内分泌科云南省第一人民医院[23]Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, P.R. China中山大学附属第二医院[24]Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China[25]Department of Endocrinology and Metabolism, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet 850000, P.R. China[26]Department of Endocrinology, Qinghai Provincial People's Hospital, Xining, Qinghai 810000, P.R. China[27]Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, P.R. China[28]Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou 550004, P.R. China[29]Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China[30]Department of Endocrinology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China[31]Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China[32]Department of Endocrinology and Metabolism and the institute of Endocrinology, Rui-Jin Hospital affiliated with Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, P.R. China[33]Department of Endocrinology, Shandong Provincial Hospital affiliated with Shandong University, Jinan, Shandong 250000, P.R. China
Background:Iodine is important in both thyroid function and human metabolism. Studies have explored the effect of iodine on metabolic disorders through thyroid function. This study aimed to investigate the relationship between iodine status and metabolic disorders, such as metabolic syndrome (MetS), hypertension, impaired glucose metabolism, central obesity, and dyslipidemia. Methods:A total of 51,795 subjects aged ≥18 years from the TIDE (Thyroid Disorders, Iodine Status and Diabetes, a national epidemiological cross-sectional study) program were included. The prevalence of metabolic disorders and its related diseases was calculated based on the level of urinary iodine concentrations (UICs) using the chi-square method. To further explore whether the prevalence was associated with UIC, quadratic and UIC-stratified logistic regression models were used. Results:The prevalence of metabolic disorders as a function of UIC was found to be U-shaped with a lower prevalence of 76.0% at an UIC of 300-499 μg/L. Participants with an UIC of 300-499 μg/L showed an association with metabolic disorders (odds ratio [OR] = 0.857, 95% confidence interval [CI 0.796-0.922]) and hypertension (OR = 0.873 [CI 0.814-0.936]). An UIC of 300-799 μg/L was found to be associated with the occurrence of MetS and impaired glucose tolerance. An UIC of 500-799 μg/L was associated with the occurrence of prediabetes (OR = 0.883 [CI 0.797-0.978]). An UIC of ≥300 μg/L was associated with the occurrence of hypertriglyceridemia, hypercholesterolemia, and high levels of low-density lipoprotein cholesterol. Furthermore, an UIC of <100 μg/L showed an association with hypertension (OR = 1.097 [CI 1.035-1.162]) and hypercholesterolemia (OR = 1.178 [CI 1.117-1.242]). Conclusions:The association between UICs in adults and metabolic disorders and its related diseases is U-shaped. The association between UIC and metabolic disorders disappears in cases of iodine deficiency (<100 μg/L) or excess (≥500 μg/L).
基金：
This work was supported by the Research Fund for Public Welfare from National Health and Family Planning Commission of China (Grant No. 201402005). Scientific Bolstering Project of Sichuan Province (Grant No.2014SZ0005).
第一作者机构：[1]Department of Endocrinology and Metabolism and the Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Endocrinology and Metabolism and the Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China[*1]Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, Shenyang 110001, P.R. China[*2]The Institute of Endocrinology, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, Shenyang 110001, P.R. China
推荐引用方式(GB/T 7714)：
Mingyue Jin,Zhuo Zhang,Yongze Li,et al.U-Shaped Associations Between Urinary Iodine Concentration and the Prevalence of Metabolic Disorders: A Cross-Sectional Study.[J].THYROID.2020,30(7):1053-1065.doi:10.1089/thy.2019.0516.
APA：
Mingyue Jin,Zhuo Zhang,Yongze Li,Di Teng,Xiaoguang Shi...&Zhongyan Shan.(2020).U-Shaped Associations Between Urinary Iodine Concentration and the Prevalence of Metabolic Disorders: A Cross-Sectional Study..THYROID,30,(7)
MLA：
Mingyue Jin,et al."U-Shaped Associations Between Urinary Iodine Concentration and the Prevalence of Metabolic Disorders: A Cross-Sectional Study.".THYROID 30..7(2020):1053-1065
医学