高级检索
当前位置: 首页 > 详情页

The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey(Open Access)

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China MedicalUniversity, Shenyang, China [2]Department of Endocrinology, The First People’s Hospital of Yunnan Province, Kunming,China [3]Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou,China [4]Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China [5]Department ofEndocrinology and Metabolism, People’s Hospital of Tibet Autonomous Region, Lhasa, China [6]Department ofEndocrinology, Qinghai Provincial People’s Hospital, Xining, China [7]Department of Endocrinology, Chinese PLA GeneralHospital, Beijing, China [8]Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing,China [9]Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China [10]Departmentof Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China [11]Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China [12]Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China [13]Department ofEndocrinology, Hohhot First Hospital, Hohhot, China [14]Department of Endocrinology and Metabolism, The Second XiangyaHospital, Central South University, Changsha, China [15]Research Center of Endocrine and Metabolic Diseases, AffiliatedHospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China [16]Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital,Fuzhou, China [17]Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, ZhengzhouUniversity, Zhengzhou, China [18]Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning,China [19]Department of Endocrinology, Hainan General Hospital, Haikou, China [20]Department of Endocrinology, The FirstAffiliated Hospital of Xi’an Jiaotong University, Xi’an, China [21]Department of Endocrinology, Union Hospital, Tongji MedicalCollege, Huazhong University of Science and Technology, Wuhan, China [22]Department of Endocrinology, The First Hospitalof Lanzhou University, Lanzhou, China [23]State Key Laboratory of Biotherapy, Department of Endocrinology and Metabolism,West China Hospital, Sichuan University, Chengdu, China [24]Department of Endocrinology and Metabolism, The FirstHospital of Jilin University, Changchun, China [25]Department of Endocrinology, Shanghai University of Medicine & HealthScience Affiliated Zhoupu Hospital, Shanghai, China [26]Department of Endocrinology, The First Hospital of Anhui MedicalUniversity, Hefei, China [27]Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China [28]Department ofEndocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China [29]Department ofEndocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China [30]Department of Endocrinology, The FirstAffiliated Hospital of Xinjiang Medical University, Ürümqi, China [31]Department of Endocrinology and Metabolism, TianjinMedical University General Hospital, Tianjin, China
出处:
ISSN:

关键词: glucose hypertriglyceridemia IFG lipid TgAb TPOAb

摘要:
Purpose: The expressions of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera of patients with autoimmune thyroid diseases (AITD). The relationship between thyroid autoantibodies and the occurrence of glucose and lipid metabolic disorders remains unclear. This study was performed to investigate the correlation between the presence of serum TPOAb/TgAb and those metabolic disorders in euthyroid general population. Methods: The data of this study were derived from the Thyroid Disease, Iodine status, and Diabetes National epidemiological (TIDE) survey from all 31 provinces of mainland China. A total of 17,964 euthyroid subjects including 5,802 males (4,000 with TPOAb−TgAb− and 1,802 with TPOAb+/TgAb+) and 12,162 females (8,000 with TPOAb−TgAb− and 4,162 with TPOAb+/TgAb+) were enrolled in this study. The blood glucose and lipid levels were compared between individuals with TPOAb−TgAb− and those with TPOAb+TgAb−, TPOAb−TgAb+, TPOAb+TgAb+. Results: Both fasting blood glucose (FBG) concentration and the proportion of individuals with impaired FBG (IFG) showed the decreased trends in TPOAb−TgAb+ males as compared with TPOAb−TgAb− men. There were significantly lower FBG and higher HDL-C levels as well as tendencies toward decreased incidences of IGT and hypertriglyceridemia in TPOAb−TgAb+ females when compared with TPOAb−TgAb− women. Binary logistic regression analysis further showed that serum TgAb single positivity in males was an independent protective factor for IFG with an OR of 0.691 (95% CI, 0.503–0.949). For females, serum TgAb single positivity was an independent protective factor for hypertriglyceridemia with an OR of 0.859 (95% CI, 0.748–0.987). Trend test showed that with the increase of serum TgAb level, there were significant decreases in the prevalence of IFG among the men with TSH ≤ 2.5 mIU/L and that of hypertriglyceridemia in the women, especially among non-obese females. Conclusion: Serum TgAb single positivity may imply a reduced risk of IFG in euthyroid men and that of hypertriglyceridemia in euthyroid women. The mechanisms for the independent protective roles of TgAb await further investigation. © Copyright © 2020 Zhang, Gao, Li, Teng, Xue, Yan, Yang, Yang, Yao, Ba, Chen, Du, He, Lai, Teng, Shi, Li, Chi, Liao, Liu, Liu, Qin, Qin, Quan, Shi, Sun, Tang, Tong, Wang, Zhang, Wang, Ye, Zhang, Zhang, Zhu, Zhu, Teng, Shan and Li.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2020]版:
大类 | 3 区 医学
小类 | 3 区 内分泌学与代谢
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
JCR分区:
出版当年[2019]版:
Q2 ENDOCRINOLOGY & METABOLISM
最新[2023]版:
Q2 ENDOCRINOLOGY & METABOLISM

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者:
第一作者机构: [1]Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China MedicalUniversity, Shenyang, China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:82478 今日访问量:0 总访问量:681 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 云南省第一人民医院 技术支持:重庆聚合科技有限公司 地址:云南省昆明市西山区金碧路157号