机构：[1]Department of Endocrinology and Metabolism and the institute of Endocrinology,The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China, 110001[2]Department of Endocrinology, the First Hospital of Lanzhou University, Lanzhou, Gansu,P.R. China, 730000[3]Department of Endocrinology and Metabolism, State Key Laboratoryof Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China,610041四川大学华西医院[4]Department of Endocrinology and Metabolism, The First Hospital of JilinUniversity, Changchun, Jilin, P.R. China, 130021[5]Department of Endocrinology, ShanghaiUniversity of Medicine & Health Science Affiliated Zhoupu Hosipital, Shanghai, P.R. China,201318[6]Department of Endocrinology, The First Hospital of An Hui Medical University,Hefei, Anhui, P.R. China, 230000[7]Department of Endocrinology, Chinese PLA GeneralHospital, Beijing, P.R. China, 100853[8]Department of Endocrinology, Southwest Hospital,Third Military Medical University, Chongqing, P.R. China, 400038[9]Department ofEndocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning,P.R. China, 116011大连医科大学附属第一医院[10]Department of Endocrinology, Cardiovascular and CerebrovascularDisease Hospital of Ningxia Medical University, Yinchuan, Ningxia, P.R. China, 750004[11]Department of Endocrinology and Metabolism, The Second Affiliated Hospital ofNanchang University, Nanchang, Jiangxi, P.R. China, 330006[12]Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University,Harbin, Heilongjiang, P.R. China, 150001[13]Department of Endocrinology, Hohhot FirstHospital, Hohhot, Inner Mongolia, P.R. China, 010000[14]Department of Endocrinology andMetabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R.China, 410011[15]Research center of Endocrine and Metabolic Diseases, Affiliated Hospitalof Integrated Traditional Chinese and Western Medicine, Nanjing University of ChineseMedicine, Nanjing, Jiangsu, P.R. China, 210028[16]Department of Endocrinology andMetabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital,Fuzhou, Fujian, P.R. China, 350001[17]Division of Endocrinology, Department of InternalMedicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, P.R.China, 450052[18]Department of Endocrine, First Affiliated Hospital of Guangxi MedicalUniversity, Nanning, Guangxi, P.R. China, 530021[19]Department of Endocrinology, HainanGeneral Hospital, Haikou, Hainan, P.R. China, 570311[20]Department of Endocrinology, theFirst Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, P.R. China, 710061[21]Department of Endocrinology, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei, P.R. China, 430022华中科技大学同济医学院附属协和医院[22]Department ofEndocrinology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, P.R.China, 650032内科片内分泌科云南省第一人民医院[23]Department of Endocrinology and Metabolism, Sun Yat-sen MemorialHospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China, 510120[24]Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan,Shanxi, P.R. China, 030001[25]Department of Endocrinology and Metabolism, People'sHospital of Tibet Autonomous Region, Lhasa, Tibet, P.R. China, 850000[26]Department ofEndocrinology, Qinghai Provincial People's Hospital, Xining, Qinghai, P.R. China, 810000[27]Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R.China, 310051[28]Department of Endocrinology and Metabolism, Affiliated Hospital ofGuiyang Medical University, Guiyang, Guizhou, P.R. China, 550004[29]Department ofEndocrinology, Second hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R.China, 050000[30]Department of Endocrinology, the First Affiliated Hospital of XinjiangMedical University, Urumqi, Xinjiang, P.R. China, 830054[31]Department of Endocrinologyand Metabolism, Tianjin Medical University General Hospital, Tianjin, P.R. China, 300052
Studies have shown that metabolic abnormalities influence the immune system. Because the prevalence of metabolic and autoimmune thyroid diseases has increased synchronously, the correlation between them was worth exploring. The study objective was to investigate the relationship between metabolic disorders and thyroid autoantibodies in euthyroid subjects.Data were obtained from a TIDE project survey of 55,891 subjects from 31 provinces in China. The body mass index(BMI), waist circumference(WC), blood pressure(BP), TPOAb, TgAb, TSH, UIC, blood glucose, lipid profile, uric acid(UA) levels were evaluated. FT4 and FT3 levels were measured in patients with abnormal serum TSH levels.In males, the BMI, WC, SBP, DBP, and OGTT2hPG of the TPOAb/TgAb-positive groups were significantly higher than those of the TPOAb/TgAb-negative groups. In females, the BMI, WC, SBP, DBP, TC, and LDL-C in the TPOAb/TgAb-positive groups were significantly increased compared to those in the TPOAb/TgAb-negative groups. Multivariate analysis showed that, in males, the OR of positive TgAb in the abdominal obesity group was 1.175 (95% CI 1.016-1.359, P for difference= 0.03), and the OR of positive TPOAb in the hyperuricemia group was 1.195 (95% CI 1.041-1.372, P for difference = 0.011). In females, the OR of positive TgAb was 1.19 (95% Cl 1.068-1.326, P for difference= 0.002) in the high LDL-C group.Obesity, high LDL-C and hyperuricemia were positively correlated with the prevalence of positive thyroid autoantibodies in euthyroid subjects in a gender-dependent manner. Summary This cross-sectional survey showed that metabolic disorders are associated with increased positive thyroid autoantibody levels in euthyroid subjects in a gender-dependent manner.
基金：
This study was funded by the Research Fund for Public Welfare, National Health and Family Planning Commission of China (Grant No. 201402005) , the Clinical Research Fund of Chinese Medical Association (Grant No. 15010010589) and the National Nature Science Foundation of China (Grant No.8187031480, U1508219)
第一作者机构：[1]Department of Endocrinology and Metabolism and the institute of Endocrinology,The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China, 110001
共同第一作者：
通讯作者：
通讯机构：[1]Department of Endocrinology and Metabolism and the institute of Endocrinology,The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China, 110001[*1]Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155, Nanjing Bei street, Shenyang, P.R. China, 110001.[*2]The institute of Endocrinology ,The First Hospital of China Medical University, No. 155, Nanjing Bei street, Shenyang, P.R. China, 110001
推荐引用方式(GB/T 7714)：
Ying Wu,Xiaoguang Shi,Xulei Tang,et al.THE CORRELATION BETWEEN METABOLIC DISORDERS AND TPOAB/TGAB: A CROSS-SECTIONAL POPULATION-BASED STUDY.[J].ENDOCRINE PRACTICE.2020,26(8):869-882.doi:10.4158/EP-2020-0008.
APA：
Ying Wu,Xiaoguang Shi,Xulei Tang,Yongze Li,Nanwei Tong...&Zhongyan Shan.(2020).THE CORRELATION BETWEEN METABOLIC DISORDERS AND TPOAB/TGAB: A CROSS-SECTIONAL POPULATION-BASED STUDY..ENDOCRINE PRACTICE,26,(8)
MLA：
Ying Wu,et al."THE CORRELATION BETWEEN METABOLIC DISORDERS AND TPOAB/TGAB: A CROSS-SECTIONAL POPULATION-BASED STUDY.".ENDOCRINE PRACTICE 26..8(2020):869-882
