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LncRNA LA16c‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity

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收录情况： ◇ SCIE

作者：
WEIJUAN XIN[1] * ; SHUTING ZHAO[2] * ; XUESONG HAN[3] * ; PENG ZHAO[4] ; HUI YU[5] ; XIAODONG GAO[2] ; PING LI[6] ; QIANYU WU[2] ; JINGXIN DING[1,*1] ; KEQIN HUA[1,*1] ;
机构： [1]Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090 [2]Department of Obstetrics and Gynecology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120 [3]Department of Gynecology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032 [4]Department of Internal Medicine, People's Hospital of Dezhou, Dezhou, Shandong 253001 [5]Clinical Nursing Staff Room, Department of Medicine, Dezhou University, Dezhou, Shandong 253023 [6]Department of Obstetrics and Gynecology, The Second People's Hospital of Dongying, Dongying, Shandong 257335, P.R. China
出处：
DOI： 10.3892/ijo.2020.5046
ISSN：

关键词： Competing endogenous RNA Endometrial cancer Long non-coding RNA LA16c-313D11 11 MicroRNA-205-5p PTEN

摘要：
The aim of the present study was to determine the competitive endogenous RNA (ceRNA) network associated with long-coding RNA (lncRNA) LA16c-313D11.11 in endometrial cancer (EC). Initially, the expression levels of LA16c-313D11.11 in 60 EC tissues, 20 atypical hyperplasia endometrium (EAH) tissues and 20 normal endometrium tissues was determined. MicroRNA (miRNA/miR)-205-5p mimics and LA16c-313D11.11 mimics were transfected into HEC-1A and Ishikawa cells. The expression levels of miR-205-5p, LA16c-313D11.11 and their target proteins were assessed using reverse transcription-quantitative PCR or western blot analysis. Flow cytometry, Cell Counting kit-8 assays, Transwell migration assays and wound healing assays were performed to assess the effects of LA16c-313D11.11 and miR-205-5p on the migration and proliferation of tumor cells in vitro. The expression levels of LA16c-313D11.11 and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in human EAH and EC tissues were significantly decreased, whereas the expression levels of miR-205-5p in EAH and EC tissues were significantly increased, compared with the normal endometrium tissues. The expression of LA16c-313D11.11 in human EC tissues negatively correlated with the expression of miR-205-5p. Additionally, the overexpression of LA16c-313D11.11 significantly reduced the invasion, migration and viability of HEC-1A and Ishikawa cells in vitro. LA16c-313D11.11 was shown to regulate the expression of PTEN, and the invasion, migration and viability of HEC-1A and Ishikawa cells, through its microRNA response element to compete for microRNA-205-5p. LA16c-313D11.11 was also shown to modulate the PI3K/AKT signaling pathway. Therefore, LA16c-313D11.11 acts as an effective ceRNA associated with a microRNA-205-5p-PTEN axis. LA16c-313D11.11 may inhibit the development and progression of EC by acting as a sponge of miR-205-5p, thus indirectly increasing the expression of PTEN. © 2020 Spandidos Publications. All rights reserved.

基金：
The present study was subsidized by the Natural Science Foundation of Shanghai, China (grant no. 16ZR1404100).
语种：
外文
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WOS：
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
JCR分区：
出版当年[2019]版：
Q2 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090
共同第一作者：
通讯作者：
通讯机构： [1]Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090 [*1]Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen‑Yang Road, Shanghai 200090, P.R. China
推荐引用方式(GB/T 7714)：
WEIJUAN XIN,SHUTING ZHAO,XUESONG HAN,et al.LncRNA LA16c‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity[J].INTERNATIONAL JOURNAL OF ONCOLOGY.2020,57(1):355-363.doi:10.3892/ijo.2020.5046.
APA：
WEIJUAN XIN,SHUTING ZHAO,XUESONG HAN,PENG ZHAO,HUI YU...&KEQIN HUA.(2020).LncRNA LA16c‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity.INTERNATIONAL JOURNAL OF ONCOLOGY,57,(1)
MLA：
WEIJUAN XIN,et al."LncRNA LA16c‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity".INTERNATIONAL JOURNAL OF ONCOLOGY 57..1(2020):355-363

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