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Multivariate analysis for prognostic factors of 282 patients with hepatic encephalopathy

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机构： [1]Department of Gastroenterology, Tianjin 4th Centre Hospital, The Clinical Medicine of Tianjin Medical University, Tianjin 300140, China [2]Department of Medical Clinic, Tianjin 4th Centre hospital, Tianjin 300140, China [3]Department of Neurology, The 4th Central Hospital, Tianjin 300140, China [4]Department of Hepatobiliary Surgery, The First People’s Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming Medical College, Kunming 650032, China [5]Department of Neurosurgery, Kunming Children’s Hospital, Kunming 650030, China.

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关键词： Hepatic encephalopathy Hyponatremia Multivariate analysis Prognosis Risk factors

摘要：

Objective: To explore the prognostic factors of hepatic encephalopathy (HE) for survival. Methods: We retrospectively reviewed the clinical data of 282 hepatic encephalopathy patients from January 2012 to May 2014 in our hospital. Data base was built using Excel and SPSS 18.0. Multivariate logistic regression statistics were used to analyze 21 possible risk factors, including gender, age, ALB, ALT, K+, Na+, Cl-, PH, TBIL, TBA, PT, APTT, UREA, Ca+, Mg+, P, NH3, PaCO2, PaO2, HCO3 - and TCO2. Results: The mortality rate of the 282 HE patients was 73.8%. There was statistical difference in Na+, NH3, APTT, UREA and ALT. These five factors indicated poor prognosis of patients with hepatic encephalopathy, whose overall percentage correct was 83.0% and a predictive model: logit(P)=1.638×Na+ (mmol/L) - 2.295×NH3 (umol/L) - 1.812×APTT (sec) - 1.738×UREA (mmol/L) - 1.315×ALT (IU/L) + 3.340 was developed. Conclusion: The prognosis of patients with hepatic encephalopathy have a variety of factors, hyponatremia, hyperammonemia, prolonged APTT, high urea and high ALT were found to be potential risk factors for prognosis of hepatic encephalopathy. Monitoring these factors may be helpful to detect the development of hepatic encephalopathy in time. © 2016, E-Century Publishing Corporation. All rights reserved.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

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第一作者机构： [1]Department of Gastroenterology, Tianjin 4th Centre Hospital, The Clinical Medicine of Tianjin Medical University, Tianjin 300140, China

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通讯机构： [4]Department of Hepatobiliary Surgery, The First People’s Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming Medical College, Kunming 650032, China [5]Department of Neurosurgery, Kunming Children’s Hospital, Kunming 650030, China. [*1]Department of Hepatobiliary Surgery, The First People’s Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming Medical College, Kunming 650032, China [*2]Department of Neurosurgery, Kunming Children’s Hospital, Kunming 650030, China

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