机构：[1]Department of Obstetrics and Gynaecology, The First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming 650032, Yunnan, China外科片产科妇科云南省第一人民医院[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China云南省第一人民医院[3]Dali University, Dali 671003, Yunnan, China
Purpose There are limited data regarding postoperative complications and autoimmune reactions caused by surgery in early-stage cervical cancer patients who underwent laparoscopic radical resection (LRR). This study aimed to investigate the therapeutic effect of LRR of cervical cancer patients and its effect on cytokines. Methods 168 patients with cervical cancer were enrolled. The patients were divided into open group and laparoscopic group according to the random number table method, with 84 cases in each group. The surgical-related indexes and the incidence of complications of the two groups were observed, and the IFN-gamma, TNF, and IL-1/2/4/6/8/10/12 levels in peripheral blood were compared before and after surgery in both groups. Results The operation time of the patients in the laparoscopic group was significantly shorter than that in the open group (119.56 +/- 45.26 vs. 206.36 +/- 54.39, P < 0.01). The intraoperative blood loss in the laparoscopic group was significantly less than that in the open group (155.29 +/- 57.58 vs. 529.58 +/- 162.4, P < 0.01). The postoperative visual analog scale (VAS) score was also significantly lower than that in the open group (3.65 +/- 0.88 vs. 6.32 +/- 1.12, P < 0.01). There was no significant difference in the incidence of complications between the two groups. The degree of inflammatory cytokines changes caused by LRR was less than that of open radical surgery (P < 0.001). Conclusions LRR surgery has less stress on patients with early cervical cancer than open surgery within 5 days after surgery, which has certain reference value for early cervical cancer treatment.
基金：
This study was supported by Health Science and Technology
Plan Projects of Yunnan Province (Grant Nos.: 2016NS195 and
2016NS196), Provincial Innovation Team Project of Human Assisted
Reproductive Technology Research (Grant No.: 2017HC009), Martin
Expert Workstation (Grant No.: 2018IC106), Special Project of
Yunnan "Ten Thousand Plan · Famous Doctor" (Grant No.: YNWRMY-
2018–014), Clinical Medical Center of Yunnan Provincial Health
Commission (Grant No.: ZX2019-01–01), and National Natural Science
Foundation of China (Grant No.: 31700798).
第一作者机构：[1]Department of Obstetrics and Gynaecology, The First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming 650032, Yunnan, China[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynaecology, The First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming 650032, Yunnan, China[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China
推荐引用方式(GB/T 7714)：
Xu Qin,Dong Mingfeng,Dong Wei,et al.Postoperative comparison of laparoscopic radical resection and open abdominal radical hysterectomy for cervical cancer patient[J].ARCHIVES OF GYNECOLOGY AND OBSTETRICS.2020,302(2):473-479.doi:10.1007/s00404-020-05606-2.
APA：
Xu, Qin,Dong, Mingfeng,Dong, Wei,Yang, Dehong,Zhang, Jie...&Feng, Yun.(2020).Postoperative comparison of laparoscopic radical resection and open abdominal radical hysterectomy for cervical cancer patient.ARCHIVES OF GYNECOLOGY AND OBSTETRICS,302,(2)
MLA：
Xu, Qin,et al."Postoperative comparison of laparoscopic radical resection and open abdominal radical hysterectomy for cervical cancer patient".ARCHIVES OF GYNECOLOGY AND OBSTETRICS 302..2(2020):473-479
