机构：[1]Department of Blood Transfusion, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China医技片输血科云南省第一人民医院[2]Department of State‐owned Assets Management, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China云南省第一人民医院[3]Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China[4]Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China[5]Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China
BackgroundGenetic polymorphisms in numerous pharmacogenetics studies were regarded as the essential factors involved in the response to or metabolism of drugs. These genetic variants called very important pharmacogenetic (VIP) variants played a role in drugs metabolism, which have been summarized in the PharmGKB database. In this study, we genotyped 80 VIP variants from the PharmGKB in 100 members of Blang volunteers from Yunnan province. MethodsBased on the PharmGKB database, we genotyped 80 VIP variants loci located in 47 genes. We used (2) tests to evaluate the significant loci between Blang and the other populations, including ASW, CEU, CHB, CHD, GIH, JPT, LWK, MEX, MKK, TSI, and YRI. The global variation distribution of the significant variants was observed from the ALlele FREquency Database. And then, we used F-statistics (Fst), genetic structure, and phylogenetic tree analyses to ascertain the genetic affinity among 12 populations. ResultsComparing the Blang with the other 11 populations from the HapMap Project, the statistical results revealed that rs3814055 (NC_000003.12:g.119781188C>T) of nuclear receptor subfamily 1 group I member 2 (NR1I2, OMIM# 603,065) was the most significant variant, followed by rs1540339 (NC_000012.12:g.47863543C>T) of vitamin D receptor (VDR, OMIM#601,769). Furthermore, we found that genotype frequency of rs3814055 in the Blang was closer to the populations distributed in Miao. And genetic structure and F-statistics indicated that the Blangs had a relatively closer affinity with CHD, CHB, and JPT populations. In addition, the Han nationality in Shaanxi was closer to it. ConclusionsOur results will complement the pharmacogenomics information of the Blang ethnic group and provide a theoretical basis for safer drug administration for Blang.
基金：
This work is supported by the study of genetic background
difference about cytochrome P450 enzyme (CYP450) in
Wa and Blang populations from Yunnan province (No.
2017FE468(‐125)).
第一作者机构：[1]Department of Blood Transfusion, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Blood Transfusion, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China[*1]Department of Blood Transfusion, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
推荐引用方式(GB/T 7714)：
Zhang Chan,Guo Weiwei,Cheng Yujing,et al.Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China[J].MOLECULAR GENETICS & GENOMIC MEDICINE.2019,7(5):doi:10.1002/mgg3.574.
APA：
Zhang, Chan,Guo, Weiwei,Cheng, Yujing,Li, Qi,Yang, Xin...&Chen, Wanlu.(2019).Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China.MOLECULAR GENETICS & GENOMIC MEDICINE,7,(5)
MLA：
Zhang, Chan,et al."Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China".MOLECULAR GENETICS & GENOMIC MEDICINE 7..5(2019)
