TNF-induced protein 2 (TNFAIP2) is a primary response gene of TNF alpha. TNFAIP2 is highly expressed in immune cells and the urinary bladder. The expression of TNFAIP2 is regulated by multiple transcription factors and signalling pathways, including NF-kappa B, KLF5 and retinoic acid. Physiologically, TNFAIP2 appears to be a multiple functional mediator not only for inflammation, angiogenesis and tunneling nanotube (TNT) formation but also as a regulator of cell proliferation and migration. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer.
基金：
Department of Education, Yunnan Province of China [2016ZZX202]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China [31771516, 81672624, U1602221]; Diagnosis, Treatment and Transformation Engineering Technology Research Center for Renal Cell Carcinoma of Yunnan Province [2016DNH001]
第一作者机构：[1]Yuxi Normal Univ, Dept Biol, Yuxi, Peoples R China
通讯作者：
通讯机构：[2]Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China[*1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式(GB/T 7714)：
Jia Lin,Shi Yundong,Wen Yi,et al.The roles of TNFAIP2 in cancers and infectious diseases[J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2018,22(11):5188-5195.doi:10.1111/jcmm.13822.
APA：
Jia, Lin,Shi, Yundong,Wen, Yi,Li, Wei,Feng, Jing&Chen, Ceshi.(2018).The roles of TNFAIP2 in cancers and infectious diseases.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,22,(11)
MLA：
Jia, Lin,et al."The roles of TNFAIP2 in cancers and infectious diseases".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 22..11(2018):5188-5195
医学