机构：[1]The Obstetrical Department of the First People's Hospital of Yunnan Province (The Affiliated Hospital of Kunming University of Science and Technology), Kunming 650500, China外科片产科云南省第一人民医院[2]Faculty of Environmental Science & Engineering, Kunming University of Science & Technology, Kunming 650500, China [3]Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA 01003, USA
The accumulation and transfer of carcinogens, including polycyclic aromatic hydrocarbons (PAHs), in the human body, especially from mother to fetus, has been the subject of many research studies, but the related data are limited and the mechanisms are unknown. This is the first study to investigate the distribution of PAHs in paired samples of maternal blood, placenta tissue, and umbilical cord blood in relation to pregnancy complications. Sixty-four pairs of samples were collected in Kunming, China; 18 were from healthy pregnant women and 46 were from patients with pregnancy complications. The predominant PAHs in these pregnant women were high-molecular-weight (HMW) compounds, mainly from the incomplete combustion or pyrolysis of biomass. In the control group, the total amount of HMW compounds (Sigma(HMW)PAHs) was significantly higher in maternal blood than in umbilical cord blood, which suggested that placenta may decrease PAH transfer in healthy pregnant women. However, this phenomenon was not observed for low-molecular-weight PAHs or in the case group. In the control group, Sigma(16)PAH and Sigma(HMW)PAH in the placenta were higher than those in maternal blood and umbilical cord blood; for the case group, a contrasting result was observed. SHMWPAHs in the placenta was significantly higher in the control group than in the case group. The same results were observed after the exclusion of the impact of the genotypes of the PAH metabolic enzymes (both phase I and phase II enzymes). Thus, the decreased PAH transfer from mother to fetus may partially result from the accumulation of PAHs inside the placenta. (C) 2018 Elsevier B.V. All rights reserved.
基金：
National Natural Scientific Foundation of ChinaNational Natural Science Foundation of China [41725016, U1602231, 41663013]; Yunnan International Cooperation project [2017IB004]; Provincial Innovation Team [2017HC008]
第一作者机构：[1]The Obstetrical Department of the First People's Hospital of Yunnan Province (The Affiliated Hospital of Kunming University of Science and Technology), Kunming 650500, China
通讯作者：
推荐引用方式(GB/T 7714)：
Dong Xudong,Wang Qibing,Peng Juan,et al.Transfer of polycyclic aromatic hydrocarbons from mother to fetus in relation to pregnancy complications[J].SCIENCE OF THE TOTAL ENVIRONMENT.2018,636:61-68.doi:10.1016/j.scitotenv.2018.04.274.
APA：
Dong, Xudong,Wang, Qibing,Peng, Juan,Wu, Min,Pan, Bo&Xing, Baoshan.(2018).Transfer of polycyclic aromatic hydrocarbons from mother to fetus in relation to pregnancy complications.SCIENCE OF THE TOTAL ENVIRONMENT,636,
MLA：
Dong, Xudong,et al."Transfer of polycyclic aromatic hydrocarbons from mother to fetus in relation to pregnancy complications".SCIENCE OF THE TOTAL ENVIRONMENT 636.(2018):61-68
环境科学与生态学