机构：[1]Department of Cardiology, The Third People’s Hospital of Yunnan Province, The Second Affiliated Hospital of Dali University, Kunming, Yunnan, China[2]Pathogenic Organisms Department of Experimental Center, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China[3]Department of Geriatrics,The First People’s Hospital of Yunnan Province,Kunming,Yunnan,China云南省第一人民医院内科片干部保健科/老年医学[4]Department of Pharmacy, The Third People’s Hospital of Yunnan Province, Kunming, Yunnan, China[5]Department of Lab Testing, The Third People’s Hospital of Yunnan Province, Kunming, Yunnan, China[6]Department of Research and Education, The Third People’s Hospital of Yunnan Province, Kunming, Yunnan, China[7]Faculty of Clinical Medicine, Dali University, Kunming, Yunnan, China
T regulatory type 1 (Tr1) cells can promote tolerance and suppress inflammation. Atherosclerosis may be induced by the proinflammatory activation of cells in the vasculature and the immune system. Hence, we wondered whether defects in Tr1 function were a contributing factor to coronary artery disease (CAD). Data showed that the frequency of IL-10+Tr1 cells was significantly lower in CAD patients than in controls. Compared to healthy controls, Tr1 cells from CAD patients presented lower CTLA-4 but higher PD-1 expression, in addition to lower IL-10 secretion. When co-incubated with Tconv cells, the CD4(+)CD49b(+)LAG-3(+)CD45RO(+) Tr1 cells presented IL-10-dependent inhibitory effects, and those from CAD patients presented significantly lower suppression capacity than those from healthy controls. Interestingly, the characteristics of Tr1 cells were associated with clinical features of CAD patients. The frequency of Tr1 cells and the IL-10 and LAG-3 expression by Tr1 cells were negatively correlated with the BMI of the CAD patients. In addition, the Tr1 frequency and the LAG-3 and CTLA-4 expression on Tr1 cells were lower in CAD patients with higher numbers of narrowed vessels. Together, these results suggest that in CAD, Tr1 cells present multiple defects, which are associated with the clinical presentation of the disease.
基金：
Yunnan Health Science and Technology Plan Project [2014NS243]; Yunnan Science and Technology Plan Project [2012FB088]
第一作者机构：[1]Department of Cardiology, The Third People’s Hospital of Yunnan Province, The Second Affiliated Hospital of Dali University, Kunming, Yunnan, China
通讯作者：
通讯机构：[*1]Department of Cardiology, The Third People’s Hospital of Yunnan Province, 292 Beijing Road, Kunming, Yunnan, China
推荐引用方式(GB/T 7714)：
Zhu Zhendong,Ye Jiyun,Ma Yumei,et al.Function of T regulatory type 1 cells is down-regulated and is associated with the clinical presentation of coronary artery disease[J].HUMAN IMMUNOLOGY.2018,79(7):564-570.doi:10.1016/j.humimm.2018.05.001.
APA：
Zhu, Zhendong,Ye, Jiyun,Ma, Yumei,Hua, Peng,Huang, Yu...&Xia, Zhonghua.(2018).Function of T regulatory type 1 cells is down-regulated and is associated with the clinical presentation of coronary artery disease.HUMAN IMMUNOLOGY,79,(7)
MLA：
Zhu, Zhendong,et al."Function of T regulatory type 1 cells is down-regulated and is associated with the clinical presentation of coronary artery disease".HUMAN IMMUNOLOGY 79..7(2018):564-570
