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Brn2 Alone Is Sufficient to Convert Astrocytes into Neural Progenitors and Neurons

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收录情况： ◇ SCIE

作者：

机构： [1]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China. [2]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, China. [3]Kunming Enovate Institute of Bioscience, Kunming, Yunnan, China. [4]The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China.

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关键词： Brn2 reprogram astrocytes neural progenitors regenerative medicine

摘要：

Generating neurons or neural progenitor cells (NPCs) from astrocytes is a potential strategy for neurological repair by reprogramming. Previous study has showed that Brn2, by cooperating with other factors, participates in neurogenesis and neuronal reprogramming. However, it is still unclear whether the Brn2 alone can convert astrocytes into neurons or NPCs. Here, we explored the effect of Brn2 on reprogramming of astrocytes, and found that a single transcription factor Brn2 can convert mouse astrocytes into functional neurons. Furthermore, the Brn2-infected astrocytes can be induced into NPCs after changing culture condition. In addition, our study found that the reprogramming of astrocytes and the fate of transdifferentiated cells are closely associated with cell microenvironmental factors, such as the brain regions where the astrocytes come from, the proliferation ability of astrocytes, and culture condition of infected astrocytes. To sum up, for the first time, our results demonstrated that Brn2 alone is sufficient to convert astrocytes into neural progenitors and neurons, and the conversion is associated with cell microenvironments. This new conversion method will be a potential therapeutic approach to restore the injured diseased brain in regenerative medicine.

基金：

基金编号： 31760272 31360246 81300973 118115 2014FC004 2013FB100

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出版当年[2018]版：

大类 | 2 区医学

小类 | 3 区血液学 3 区医学：研究与实验 3 区移植 4 区细胞与组织工程

最新[2023]版：

大类 | 3 区医学

小类 | 3 区移植 4 区细胞与组织工程 4 区血液学 4 区医学：研究与实验

JCR分区：

出版当年[2017]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 HEMATOLOGY Q2 TRANSPLANTATION Q3 CELL & TISSUE ENGINEERING

最新[2023]版：

Q2 HEMATOLOGY Q2 TRANSPLANTATION Q3 CELL & TISSUE ENGINEERING Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.5 最新[2023版] 4.4 最新五年平均 3.315 出版当年[2017版] 3.651 出版当年五年平均 3.562 出版前一年[2016版] 3.147 出版后一年[2018版]

第一作者：

第一作者机构： [1]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China. [2]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, China. [3]Kunming Enovate Institute of Bioscience, Kunming, Yunnan, China.

共同第一作者：

通讯作者：

通讯机构： [1]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China. [3]Kunming Enovate Institute of Bioscience, Kunming, Yunnan, China. [*1]Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology Kunming 650500 China

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Brn2 Alone Is Sufficient to Convert Astrocytes into Neural Progenitors and Neurons

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