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Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke.

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机构： [1]Department of Neurosurgery, The Affiliated Hospital of Medical College, Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, China. [2]Translational Neurosurgery and Neurobiology, University Hospital Aachen, RWTH Aachen, Aachen, Germany. [3]Department of Radiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, China.

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关键词： cerebral stroke micro ribonucleic acid aquaporin 4 inflammatory response apoptosis autophagy angiogenesis

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Cerebral stroke is one of the highest-ranking causes of death and the leading cause of disability globally, particularly with an increasing incidence and prevalence in developing countries. Steadily more evidence has indicated that micro ribonucleic acids (miRNAs) have important regulatory functions in gene transcription and translation in the course of cerebral stroke. It is beyond arduous to understand the pathophysiology of cerebral stroke, due in part to the perplexity of influencing the network of the inflammatory response, brain edema, autophagy and neuronal apoptosis. The recent research shows miRNA plays a key role in regulating aquaporin 4 (AQP4), and many essential pathological processes after cerebral stroke. This article reviews the recent knowledge on how miRNA influences the inflammatory response, brain edema, infarction size, and neuronal injury after cerebral stroke. In addition, some miRNAs may serve as potential biomarkers in stroke diagnosis and therapy since the expression of some miRNAs in the blood is stable after cerebral stroke.Copyright © 2022 Zhang, Lei, Zhou, Lu, Cai and Li.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

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Q1 NEUROSCIENCES

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Q2 NEUROSCIENCES

影响因子： 4.2 最新[2023版] 5.1 最新五年平均 6.147 出版当年[2021版] 6.215 出版当年五年平均 5.505 出版前一年[2020版] 5.3 出版后一年[2022版]

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第一作者机构： [1]Department of Neurosurgery, The Affiliated Hospital of Medical College, Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, China.

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