机构：[1]Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China,昆明医科大学附属第一医院[2]Biomedicine Engineering Research Centre, Kunming Medical University, Kunming, China,[3]Department of Psychology, The First People’s Hospital of Yunnan Province, Kunming, China内科片临床心理科云南省第一人民医院
Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory cells in the central nervous system (CNS) that have been proven to be related to the pathogenesis and development of epilepsy. Additionally, interleukin 4 (IL-4) is an anti-inflammatory factor that can regulate microglia and astrocytes in many aspects. This review article focuses on the regulatory role of IL-4 in the pathological changes of glial cells related to epilepsy. We additionally propose that IL-4 may play a protective role in epileptogenesis and suggest that IL-4 may be a novel therapeutic target for the treatment of epilepsy.
基金：
This work was supported by the National Natural Science
Foundation of China (81601134, 81660228), Yunnan Applied
Basic Research Projects [2017FE468 (-144)], Program for
Science and Technology Innovation Team in Yunnan
Province (2018HC008), supported by Yunnan Health Training
Project of High-Level Talents, and also supported by China
Scholarship Council.
第一作者机构：[1]Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Lu Chen,Lin Zhu,Di Lu,et al.Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism[J].FRONTIERS IN MOLECULAR NEUROSCIENCE.2020,13:doi:10.3389/fnmol.2020.554547.
APA：
Lu Chen,Lin Zhu,Di Lu,Zhe Wu,Yanbing Han...&Qian Wu.(2020).Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism.FRONTIERS IN MOLECULAR NEUROSCIENCE,13,
MLA：
Lu Chen,et al."Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism".FRONTIERS IN MOLECULAR NEUROSCIENCE 13.(2020)
