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Three new 3-methyl-2-arylbenzofurans from the fermentation products of an endophytic fungus Phomopsis sp and their anti-TMV activity

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机构: [1]Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, PR China [2]Research and Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, PR China [3]Clinical Laboratory, First People’s Hospital of Yunnan Province, Kunming 650032, PR China
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关键词: Arylbenzofurans Phomopsis sp Anti-tobacco mosaic virus activity

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Three new arylbenzofurans, 7-methoxy-2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran (1), 2(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran-7-ol (2), 2-(4-hydroxy-3,5-dimethoxyphenyl)3- methyl-5-(3-prenyl) benzofuran-7-ol (3), along with four known arylbenzofurans (4-7) were isolated from the fermentation products of an endophytic Phomopsis sp. Their structures were elucidated by spectroscopic methods including extensive 1D-and 2D-NMR techniques. In addition, compounds 1-7 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 3 exhibited obvious anti-TMV activity with inhibition rate of 35.2% better than that of positive control (31.8%). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 18.6-25.7%, respectively. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

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出版当年[2017]版:
大类 | 4 区 生物
小类 | 4 区 药物化学 4 区 植物科学
最新[2023]版:
大类 | 4 区 生物学
小类 | 4 区 药物化学 4 区 植物科学
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出版当年[2016]版:
Q2 PLANT SCIENCES Q4 CHEMISTRY, MEDICINAL
最新[2023]版:
Q3 PLANT SCIENCES Q4 CHEMISTRY, MEDICINAL

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第一作者机构: [1]Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, PR China
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