机构：[1]Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China[2]Clinical Laboratory, First People's Hospital of Yunnan Province, Kunming 650032, PR China医技片检验科云南省第一人民医院
Three new xanthones, 1,5-dihydroxy-3-hydroxyethyl-6-methoxycarbonylxanthone (1), 1-hydroxy-5-methoxy-3-hydroxyethyl-6-methoxycarbonylxanthone (2), and 1-hydroxy-3-hydroxyethyl-8-ethoxycarbonylxanthone (3), along with seven known xanthones (4-10) were isolated from the fermentation products of an endophytic fungus Phomopsis sp.. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1-10 were also tested for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) by MU method using paclitaxel as positive control. Compounds 1 and 3 showed cytotoxicity against A549 cell lines with IC50 values of 3.6 and 2.5 mu M, respectively. In addition, 1 was cytotoxic to MCF7 cells with IC50 value of 2.7 mu M. (C) 2013 Elsevier B.V. All rights reserved.
基金：
National Natural
Science Foundation of China (No. 21302164), the excellent
Scientific and Technological Team of Yunnan High School
(2010CI08), the Yunnan University of Nationalities Green
Chemistry and Functional Materials Research for Provincial
Innovation Team (2011HC008), Applied Basic Research Combined
Project of Yunnan Technology Bureau & KunmingMedical University (2011FB124),and Open Research Fund Program of
Key Laboratory of EthnicMedicine Resource Chemistry (Yunnan
University of Nationalities) (2010XY08).
第一作者机构：[1]Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Hai-Ying,Gao Yu-Hong,Niu De-Yun,et al.Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp.[J].FITOTERAPIA.2013,91:189-193.doi:10.1016/j.fitote.2013.09.004.
APA：
Yang, Hai-Ying,Gao, Yu-Hong,Niu, De-Yun,Yang, Li-Yin,Gao, Xue-Mei...&Hu, Qiu-Fen.(2013).Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp..FITOTERAPIA,91,
MLA：
Yang, Hai-Ying,et al."Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp.".FITOTERAPIA 91.(2013):189-193
