机构：[1]Medical Faculty, Affiliated Hospital of Kunming University of Science and Technology (The First People's Hospital ofYunnan Province), Kunming University of Science and Technology, Kunming, Yunnan 650500云南省第一人民医院[2]Genetic Diagnosis Center,Key Laboratory for Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province,Kunming, Yunnan 650032, P.R. China门急诊片医学遗传科云南省第一人民医院
Varicella-zoster virus (VZV) belongs to the a-herpesvirus family. Genetically, it is stable and is divided into several genotypes based upon the genetic variations. The genotypes of VZV are rarely studied in the Southwestern region of China. In the present study, the common genetic variations in the VZV genes were examined in 42 VZV isolates collected from the patients with herpes zoster in the Yunnan province (Southwestern China). The restriction fragment length polymorphism analysis of open reading frames (ORFs) 38, 54 and 62 in the VZV genes showed that all the collected VZV isolates were PstI, BglI and SmaI positive. The R5 variable-repeat region in these isolates was variable (R5A: 46.4%; R5B: 53.6%). The sequencing data of ORFs 1, 21, 22 and 54 indicated that 41 of the 42 collected VZV isolates could be grouped into genotype J or J1. Only one VZV isolate was identified as genotype A1 or M2. No new substitutions in the sequenced fragments were found in the collected VZV isolates. The results of the present study provided a preliminary genetic characterization of the VZV strains in the Yunnan province of Southwestern China.
基金：
The present study was supported by the Education Commission of Yunnan Province (grant no. 2014Z036) and the Kunming University of Science and Technology (grant no. KKZ3201360025).
第一作者机构：[1]Medical Faculty, Affiliated Hospital of Kunming University of Science and Technology (The First People's Hospital ofYunnan Province), Kunming University of Science and Technology, Kunming, Yunnan 650500[2]Genetic Diagnosis Center,Key Laboratory for Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province,Kunming, Yunnan 650032, P.R. China[*1]Medical Faculty, Affiliated Hospital of Kunming University of Science and Technology (The First People's Hospital of Yunnan Province), Kunming University of Science and Technology, 727 Jing Ming Nan Road, Kunming, Yunnan 650500, P.R. China
通讯作者：
通讯机构：[1]Medical Faculty, Affiliated Hospital of Kunming University of Science and Technology (The First People's Hospital ofYunnan Province), Kunming University of Science and Technology, Kunming, Yunnan 650500[2]Genetic Diagnosis Center,Key Laboratory for Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province,Kunming, Yunnan 650032, P.R. China[*1]Medical Faculty, Affiliated Hospital of Kunming University of Science and Technology (The First People's Hospital of Yunnan Province), Kunming University of Science and Technology, 727 Jing Ming Nan Road, Kunming, Yunnan 650500, P.R. China[*2]Genetic Diagnosis Center, Key Laboratory for Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province, 157 Jinbi Road, Kunming, Yunnan 650032, P.R. China
推荐引用方式(GB/T 7714)：
Li Yunlong,Zhu Baosheng.Genotyping of clinical varicella-zoster virus isolates collected from Yunnan in Southwestern China[J].BIOMEDICAL REPORTS.2016,4(2):209-214.doi:10.3892/br.2015.562.
APA：
Li, Yunlong&Zhu, Baosheng.(2016).Genotyping of clinical varicella-zoster virus isolates collected from Yunnan in Southwestern China.BIOMEDICAL REPORTS,4,(2)
MLA：
Li, Yunlong,et al."Genotyping of clinical varicella-zoster virus isolates collected from Yunnan in Southwestern China".BIOMEDICAL REPORTS 4..2(2016):209-214
