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Synthesis and Antitumor Activity of a Novel Biscoumarin and its Corresponding Epoxydicoumarin

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收录情况： ◇ SCIE

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机构： [1]First Peoples Hosp Yunnan Prov, Dept Geratol, Kunming, Yunnan, Peoples R China [2]First Peoples Hosp Yunnan Prov, Dept Neurosurg, Kunming, Yunnan, Peoples R China [3]Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China [4]First Peoples Hosp Yunnan Prov, Dept Radiol, Kunming, Yunnan, Peoples R China

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关键词： antitumor biscoumarin epoxydicoumarin

摘要：

Biscoumarin (1) and its corresponding epoxydicoumarin (2) were synthesized and characterized via IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. In addition, the antitumor effects of the two compounds were studied on five human cancer cell lines including lung (A549), ovarian (SK-OV-3), melanoma (SK-MEL-2), brain (XF498), and colon (HCT15). The results showed that compared with compound 2, compound 1 displayed efficient antitumor activity.

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出版当年[2015]版：

大类 | 4 区医学

小类 | 4 区药学

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无

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出版当年[2014]版：

Q4 PHARMACOLOGY & PHARMACY

最新[2023]版：

无

影响因子： 0 最新[2023版] 0 最新五年平均 0.372 出版当年[2014版] 0.311 出版当年五年平均 0.319 出版前一年[2013版] 0.329 出版后一年[2015版]

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第一作者机构： [1]First Peoples Hosp Yunnan Prov, Dept Geratol, Kunming, Yunnan, Peoples R China

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