机构：[1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China[2]Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China[3]Neurology Department, First People’s Hospital of Yunnan Province, Kunming 650032, China内科片神经内科云南省第一人民医院
Myasthenia gravis (MG) is an autoimmune disease caused by circulating antibodies that block acetylcholine receptor (AchR) at the neuromuscular junction. There is the cognitive and memory impairment in patients with MG. However, the molecular mechanisms underlying the alteration of central nervous system in MG remain unknown. In the present study, we found that the level of malondialdehyde (MDA) was increased in the brain of experimental autoimmune myasthenia gravis (EAMG). Furthermore, the expression of thioredoxin-1 (Trx-1) and the activity of cAMP response element-binding protein (CREB) were significantly decreased in frontal lobe and hippocampus of mice with EAMG. We also found that the expression of pro-apoptotic C/EBP homologous protein (CHOP) was increased in the frontal lobe and hippocampus of mice. However, the expressions of glucose regulated protein 78 (GRP78/Bip) was not changed in same areas. Inversely, the expressions of pro-caspase-12, pro-caspase-3 and pro-caspase-9 were decreased. These data indicate that Trx-1 mediated endoplasmic reticulum and mitochondria pathways are involved in brain damage in MG. Trx-1 may be a pivotal target for brain protective treatment in MG. (C) 2014 Elsevier B.V. All rights reserved.
基金：
National Natural Science
Foundation of China (Grant No. 81160162, U1202227)
and grant from Key Laboratory of Medical
Neurobiology, Kunming University of Science and
Technology.
第一作者机构：[1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China[2]Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China[3]Neurology Department, First People’s Hospital of Yunnan Province, Kunming 650032, China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Wenli,Zeng Xiansi,Luo Fucheng,et al.The decreased expression of thioredoxin-1 in brain of mice with experimental autoimmune myasthenia gravis[J].NEUROMUSCULAR DISORDERS.2014,24(8):726-735.doi:10.1016/j.nmd.2014.05.001.
APA：
Chen Wenli,Zeng Xiansi,Luo Fucheng,Lv Tao,Zhou Xiaoshuang&Bai Jie.(2014).The decreased expression of thioredoxin-1 in brain of mice with experimental autoimmune myasthenia gravis.NEUROMUSCULAR DISORDERS,24,(8)
MLA：
Chen Wenli,et al."The decreased expression of thioredoxin-1 in brain of mice with experimental autoimmune myasthenia gravis".NEUROMUSCULAR DISORDERS 24..8(2014):726-735
