机构：[1]Department of Urology, The First People’s Hospital of Kunming, Yunnan, China,[2]Department of Urology, The Affiliated Hospital of Shanghai Jiao Tong University, Shanghai Sixth People’s Hospital, Shanghai, China.
OBJECTIVE: To evaluate the utility of a mitochondrial functional score in predicting the progress of prostate cancer. METHODS: This retrospective study included 72 patients (mean age 70.1 years) with prostate cancer who were treated by radical prostatectomy between October 2006 and March 2007. The epithelioglandular mitochondrial functional scores were assessed according to the Flameng grading. Patients were divided into six groups (groups 1 6) according to their Gleason score (Gleason score 2 7, respectively). The correlation between Gleason score and mitochondrial functional score was examined using Pearson's correlation coefficient. RESULTS: The mean mitochondrial functional score was significantly lower in group 6 compared with group 1. An inverse correlation was found between the Gleason and mitochondrial functional scores. At 1 year, significantly fewer patients in group 1 had died (0/15 patients) than in group 6 (2/10 patients); the deaths were cancer-related. CONCLUSIONS: Mitochondrial dysfunction exists in patients with prostate cancer, particularly in cases with a higher degree of malignancy. The mitochondrial functional score, combined with the Gleason score, is beneficial for predicting the progress of prostate cancer.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2011]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Urology, The First People’s Hospital of Kunming, Yunnan, China,
通讯作者：
通讯机构：[2]Department of Urology, The Affiliated Hospital of Shanghai Jiao Tong University, Shanghai Sixth People’s Hospital, Shanghai, China.[*1]Department of Urology, The Affiliated Hospital of Shanghai Jiao Tong University, Shanghai Sixth People’s Hospital, 600 Yi Shan Road, Shanghai 200233, China.
推荐引用方式(GB/T 7714)：
Sun X.,Liao N-K,Yu J-J.Prognostic Value of a Mitochondrial Functional Score in Prostate Cancer[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2012,40(1):371-376.doi:10.1177/147323001204000139.
APA：
Sun, X.,Liao, N-K&Yu, J-J.(2012).Prognostic Value of a Mitochondrial Functional Score in Prostate Cancer.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,40,(1)
MLA：
Sun, X.,et al."Prognostic Value of a Mitochondrial Functional Score in Prostate Cancer".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 40..1(2012):371-376
