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Detection of p53 protein accumulation in sputum and lung adenocarcinoma associated with indoor exposure to unvented coal smoke in China

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收录情况： ◇ SCIE

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机构： [1]U.S. Enionmental Protection Agency, Research Triangle Park, NC 27711, U.S.A. [2]University of North Carolina, Chapel Hil, NC 27599, U.SA [3]Department of Pathology, Baylor College of Medicine, Houston, TX 77030, U.S.A [4]Yunnan Provincial First People s Hospital, Kunming, China [5]Institute of Environmental Health and Engineering, Beijing, China

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关键词： lng adenocarcinoma sputum p53 protein accumulation coal combustion emissions

摘要：

Lung cancer in Xuan Wei (XW), China has been linked to exposure to unvented coal smoke and adenocarcinoma, especially bronchioloalveolar carcinoma, is most common, p53 mutations occur commonly in lung cancers and usually generate detectable levels of p53 protein accumulation. Sputum is noninvasive to collect and ideal for screening p53 abnormalities, p53 protein accumulation was detected by immunohistochemistry in lung tumors and sputa from XW lung cancer patients to determine (1) the role of p53 in lung pathogenesis, and (2) feasibility of detecting p53 protein accumulation in sputum. p53 protein accumulation was detected in 73% (22/30) of lung adenocarcinomas from XW females exposed to coal emissions and significantly higher than the control cases (33%, p<0.05). In sputum, we detected p53 overexpression in tumor cells in 54% (13/24) of XW cases and also in dysplastic cells (50% or 4/8). These findings suggest that p53 abnormalities is important in XW lung cancer etiology.

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出版当年[1999]版：

无

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[1998]版：

Q3 ONCOLOGY

最新[2023]版：

Q4 ONCOLOGY

影响因子： 1.6 最新[2023版] 1.8 最新五年平均 1.236 出版当年[1998版] 0 出版当年五年平均 1.045 出版前一年[1997版] 1.375 出版后一年[1999版]

第一作者：

第一作者机构： [1]U.S. Enionmental Protection Agency, Research Triangle Park, NC 27711, U.S.A. [*1]US Environmental Protection Agency, Research Triangle Park, NC 27711, U.S.A.

通讯作者：

通讯机构： [1]U.S. Enionmental Protection Agency, Research Triangle Park, NC 27711, U.S.A. [*1]US Environmental Protection Agency, Research Triangle Park, NC 27711, U.S.A.

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