机构：[a]Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, China医技片检验科云南省第一人民医院[b]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China云南省第一人民医院[c]Shizong County People's Hospital, Yunnan Province, China
Purpose: The purpose of this study was to determine the prevalence of human papillomavirus (HPV) in the population in Kunming, Yunnan, China, before and after the introduction of HPV preventive vaccines. Materials and Methods: In total, 28,959 patients were enrolled in this study between 1 January 2016 and 31 August 2019. HPVs were genotyped using a flow-through hybridisation technique, and differences in HPV infection rates before and after the introduction of an HPV vaccine were determined. Results: The prevalence of HPV before and after the introduction of HPV vaccines was 17.74% and 17.11%, respectively. This difference was not statistically significant (χ2 = 1.920, P > 0.05). The HPV infection rates showed a bimodal U-shaped curve for all age groups. The most common genotypes of HPV detected were HPV52, HPV16, HPV58 and HPV39. Conclusion: Although the overall HPV infection rate in Kunming did not change significantly after the introduction of HPV vaccines, differences in HPV infection rates and multi-typic HPV infection rates were evident in certain age groups.
基金：
National Natural
Science Foundation of China (No. 81960606), Yunnan Applied
Basic Research Program (Youth Project, No. 2019FD018) and
The Association Foundation Program of Yunnan Provincial
Science and Technology Department and Kunming Medical
University (No. 2017FE468 [‑124]).
第一作者机构：[a]Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, China[b]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China
通讯作者：
通讯机构：[a]Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, China[b]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China[*1]Department of Clinical Laboratory, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China.[*2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
推荐引用方式(GB/T 7714)：
Z G,D Z,X Y,et al.Human papillomavirus infection rates before and after the introduction of prophylactic vaccines in Kunming, Yunnan, China(Open Access)[J].INDIAN JOURNAL OF MEDICAL MICROBIOLOGY.2020,38(1):66-71.doi:10.4103/ijmm.IJMM_19_427.
APA：
Z, G,D, Z,X, Y,W, Q,F, X...&S, Y.(2020).Human papillomavirus infection rates before and after the introduction of prophylactic vaccines in Kunming, Yunnan, China(Open Access).INDIAN JOURNAL OF MEDICAL MICROBIOLOGY,38,(1)
MLA：
Z, G,et al."Human papillomavirus infection rates before and after the introduction of prophylactic vaccines in Kunming, Yunnan, China(Open Access)".INDIAN JOURNAL OF MEDICAL MICROBIOLOGY 38..1(2020):66-71
