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Trends in the molecular epidemiology of human papillomavirus in males from the plateau region of Southwest China: an 11-year retrospective analysis (2014-2024)

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机构： [1]Clinical Laboratory, First People's Hospital of Qujing City, Kunming Medical University Affiliated Qujing Hospital, Qujing Central Hospital of Yunnan Province, Qujing Medical College Affiliated First Hospital, Qujing, 655000, China. [2]Yunnan Provincial Key Laboratory of Public Health and Biosafety, School of Public Health, Kunming Medical University, Kunming, 650500, China. [3]Department of Anesthesiology, First People's Hospital of Qujing City, Qujing Central Hospital, Qujing, 655000, China. [4]Department of Critical Care Medicine, First People's Hospital of Qujing City, Qujing Central Hospital, Qujing, 655000, China. [5]Department of Obstetrics, First People's Hospital of Qujing City, Qujing Central Hospital, Qujing, 655000, China. [6]Department of Dermatology, First People's Hospital of Qujing City, Qujing Central Hospital, Qujing, 655000, China. [7]Digestive Medicine Center, First People's Hospital of Qujing City, Qujing Central Hospital, Qujing, 655000, China. [8]Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, 650091, China. [9]School of Basic Medical Sciences, Qujing Medical College, Qujing, 655011, China. [10]College of Agriculture and Biological Science, Key Laboratory of Bioinformatics and Computational Biology, Department of Education of Yunnan Province, Dali University, Dali, 671003, China. [11]Deparment of Orthopedics, First People's Hospital of Qujing City, Qujing Central Hospital, Qujing, 655000, China. [12]Yunnan Key Laboratory of Laboratory Medicine, Kunming, 650032, China. [13]Yunnan Province Clinical Research Center for Laboratory Medicine, Kunming, 650032, China. [14]Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. [15]Department of Cardiovasology, First People's Hospital of Qujing City, Qujing Central Hospital, Qujing, 655000, China.

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关键词： Human papillomavirus Male Molecular epidemiology Virology Genotype Plateau region of Southwest China Prevalence Vaccine

摘要：

Persistent high-risk human papillomavirus (HR-HPV) infection may increase the risk of malignancies in males, including penile, rectal, anal, prostate, bladder, and oropharyngeal cancers. However, few studies focused on the epidemiology of human papillomavirus (HPV) in male patients. This study aims to retrospectively investigate the trends of HPV molecular epidemiology in males residing in the plateau region of Southwest China from 2014 to 2024.This retrospective study investigated the trends of HPV molecular epidemiology in 3580 males residing in the plateau region of southwest China from 2014 to 2024. Samples were collected for DNA extraction, and detection of 27 HPV genotypes by Luminex xMAP technology.HPV prevalence fluctuated between 43.17% and 56.02% over the 11 years, with an average prevalence of 50.28% (1800/3580, 95% CI: 48.64%-51.92%). Among infected individuals, LR-HPV alone, HR-HPV alone, and mixed infection accounted for 71.00%, 9.83%, and 19.17%, respectively. Single, dual, triple, quadruple, and other multiple infections accounted for 73.22%, 18.28%, 5.33%, 2.22%, and 0.95%, respectively. HPV prevalence varied by clinical diagnosis: the highest in warts (76.99%, 1114/1447), followed by neoplasms (67.15%, 92/137), other diagnoses (39.10%, 364/931), rash (30.17%, 73/242), urinary inflammation (24.23%, 47/194), and asymptomatic individuals (17.49%, 110/629). Age-specific HPV prevalence exhibited a U-shaped bimodal pattern. The top five HR-HPV genotypes were HPV16 (2.35%), HPV59 (2.18%), HPV52 (1.68%), HPV56 (1.54%), and HPV39 (1.48%), while the top three LR-HPV genotypes were HPV6 (26.45%), HPV11 (16.82%), and HPV43 (1.98%). The coverage rates of the currently available bivalent, quadrivalent, and nonavalent HPV vaccines were 5.18%, 66.84%, and 73.17%, respectively. However, these vaccines do not cover HPV51, HPV39, HPV59, HPV56, HPV53, HPV43, and HPV61, which are highly prevalent genotypes in the Chinese population.These findings highlight the urgent need for developing and promoting HPV vaccines tailored to the Chinese population and accelerating HPV vaccination programs among adolescents. Integrating male HPV vaccination into the national immunization program could significantly reduce the burden of HPV-related infections and diseases.© 2025. The Author(s).

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无

最新[2025]版：

大类 | 3 区医学

小类 | 3 区病毒学

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出版当年[2024]版：

Q2 VIROLOGY

最新[2024]版：

Q2 VIROLOGY

影响因子： 3.8 最新[2024版] 3.7 最新五年平均 3.8 出版当年[2024版] 3.7 出版当年五年平均 4 出版前一年[2023版]

第一作者：

第一作者机构： [1]Clinical Laboratory, First People's Hospital of Qujing City, Kunming Medical University Affiliated Qujing Hospital, Qujing Central Hospital of Yunnan Province, Qujing Medical College Affiliated First Hospital, Qujing, 655000, China. [2]Yunnan Provincial Key Laboratory of Public Health and Biosafety, School of Public Health, Kunming Medical University, Kunming, 650500, China.

共同第一作者：

通讯作者：

通讯机构： [1]Clinical Laboratory, First People's Hospital of Qujing City, Kunming Medical University Affiliated Qujing Hospital, Qujing Central Hospital of Yunnan Province, Qujing Medical College Affiliated First Hospital, Qujing, 655000, China. [12]Yunnan Key Laboratory of Laboratory Medicine, Kunming, 650032, China. [13]Yunnan Province Clinical Research Center for Laboratory Medicine, Kunming, 650032, China. [14]Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

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Trends in the molecular epidemiology of human papillomavirus in males from the plateau region of Southwest China: an 11-year retrospective analysis (2014-2024)

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