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Curcumin promotes functional recovery and inhibits neuronal apoptosis after spinal cord injury through the modulation of autophagy

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收录情况： ◇ SCIE

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机构： [1]Faculty of Medical Science, Kunming University of Science and Technology, Kunming, People’s Republic of China, [2]Department of Orthopedic Surgery, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, People’s Republic of China, [3]Department of Cardiovascular Surgery, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, People’s Republic of China

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关键词： Akt Autophagy Curcumin mTOR Spinal cord injury

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Objective: The study was aimed to investigate whether the neuroprotective role of curcumin is associated with regulation of autophagy. Methods: Rat spinal cord injury (SCI) models were established according to Allen’s weight-drop trauma method. Curcumin was administered 30 min after the contusion and continued weekly. At 3, 7, 14, 21, and 28 days after SCI, functional recovery was evaluated using the Basso, Beattie and Bresnahan (BBB) scoring and the oblique plate test, following which, spinal cord tissues were obtained. Histological changes and apoptosis were then measured with H&E staining and TUNEL assay. Glia activation, inflammatory infiltration, inflammatory factor release, and myelination were observed through immunohistochemical (IHC) staining and ELISA. Autophagy and Akt activation were detected by western blotting. After autophagy was inhibited by injection of chloroquine, TUNEL, inflammatory factor release, myelin basic protein (MBP) IHC staining and functional recovery evaluation were performed again. Results: Curcumin treatment promoted functional recovery after SCI and reduced neuron apoptosis, improved spinal cord integrity, recovery, and re-myelination, and suppressed the inflammatory response. Autophagy was enhanced and Akt/mTOR pathway was inhibited by curcumin. Autophagy inhibition partially eliminated the protective effect of curcumin on SCI. Conclusion: Curcumin may exert its therapeutic effect on SCI through the enhancement of autophagy, in which, inhibition of the Akt/mTOR signaling pathway may be also involved. © 2019, © The Academy of Spinal Cord Injury Professionals, Inc. 2019.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区临床神经病学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学

JCR分区：

出版当年[2020]版：

Q4 CLINICAL NEUROLOGY

最新[2023]版：

Q3 CLINICAL NEUROLOGY

影响因子： 1.8 最新[2023版] 2 最新五年平均 1.985 出版当年[2020版] 2.516 出版当年五年平均 1.816 出版前一年[2019版] 2.04 出版后一年[2021版]

第一作者：

第一作者机构： [1]Faculty of Medical Science, Kunming University of Science and Technology, Kunming, People’s Republic of China, [2]Department of Orthopedic Surgery, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, People’s Republic of China,

通讯作者：

通讯机构： [2]Department of Orthopedic Surgery, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, People’s Republic of China, [*1]Department of Orthopedic Surgery, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming 650032, People’s Republic of China

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Curcumin promotes functional recovery and inhibits neuronal apoptosis after spinal cord injury through the modulation of autophagy