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Fabrication of ultrasmall WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy

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收录情况： ◇ SCIE

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机构： [a]Department of Emergency,The First People’s Hospital of Yunnan Province,Kunming University of Science and Technology,Kunming,China [b]Department of Geriatrics,The First People’s Hospital of Yunnan Province,Kunming University of Science and Technology,Kunming,China

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关键词： Chemo-photothermal therapy Drug delivery Periodic mesoporous organosilica WS2 quantum dots

摘要：

Introduction: The consolidation of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. In this study, a multifunctional platform by WS2 quantum dots (WQDs)-coated doxorubicin (DOX)-loaded periodic mesoporous organosilicas ([email protected]) nanoparticles were fabricated for the first time, and which exhibits good potential for synergistic chemo-photothermal therapy. Materials and methods: The structure, light-mediated drug release behavior, photothermal effect, and synergistic therapeutic efficiency of [email protected] to HCT-116 colon cancer cells were investigated. The thioether-bridged PMOs exhibit a high DOX loading capacity of 66.7 μg mg−1. The gating of the PMOs not only improve the drug loading capacity but also introduce the dual-stimuli-responsive performance. Furthermore, the as-synthesized [email protected] nanoparticles can efficiently generate heat to the hyperthermia temperature with near infrared laser irradiation. Results: It was confirmed that [email protected] exhibit remarkable photothermal effect and light-triggered faster release of DOX. More importantly, it was reasonable to attribute the efficient anti-tumor efficiency of [email protected] Conclusion: The in vitro experimental results confirm that the fabricated nanocarrier exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the WQD-coated PMOs present promising applications in cancer therapy. © 2018 Liao et al.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区生物工程与应用微生物 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 3 区生物工程与应用微生物 4 区肿瘤学

JCR分区：

出版当年[2017]版：

Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 ONCOLOGY

最新[2023]版：

Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 ONCOLOGY

影响因子： 2.7 最新[2023版] 3.1 最新五年平均 2.656 出版当年[2017版] 2.727 出版当年五年平均 2.612 出版前一年[2016版] 3.046 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Emergency,The First People’s Hospital of Yunnan Province,Kunming University of Science and Technology,Kunming,China

通讯作者：

通讯机构： [a]Department of Emergency,The First People’s Hospital of Yunnan Province,Kunming University of Science and Technology,Kunming,China [*1]Department of Emergency,The First People’s Hospital of Yunnan Province,Kunming University of Science and Technology,No. 727 South Jingming Rd.,Chenggong District,Kunming,Yunnan 650032,People’s Republic of China

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