详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese(Open Access)

文献详情

资源类型：

Pubmed体系：

作者：

机构： [a]Department of Urology, The First People Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, China [b]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China [c]Department of Urology, West China Hospital, Sichuan University, Chengdu, China

出处：

DOI：

关键词： Benign prostatic hyperplasia Interleukin-28B Interleukin-28B receptor α Lower urinary tract symptoms Single nucleotide polymorphism

摘要：

The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients. Genomic DNA was extracted from 553 whole blood samples from 233 patients with LUTS resulted from benign prostatic hyperplasia and 320 control subjects. The IL-28B rs12979860 and rs8099917, and IL-28Rα rs10903035 and rs11249006 polymorphisms were genotyped using a polymerase chain reaction-restriction fragment length polymorphism assay. For rs10903035, the frequencies of the “G” allele and the “AG/GG” genotypes in the LUTS group were significantly lower than those in the control group (“G” vs “A”: OR = 0.655, 95%CI = 0.506-0.849; AG/GG vs “AA”: OR = 0.538, 95%CI = 0.379-0.764, respectively). Combined effects analysis of rs12979860 and rs10903035 showed that the “CC+AG/GG” and “CT+AA” genotypes were significantly less frequent in the LUTS group (“CC+AG/GG” vs “CC+AA”: OR = 0.553, 95%CI = 0.381-0.801; “CT+AG/GG” vs “CC+AA”: OR = 0.429, 95%CI = 0.198- 0.927, respectively). In addition, the combined effects of the rs8099917 and rs10903035 “TT+AG/GG” and “GT+AG/GG” genotypes were also significantly lower in the LUTS group (“TT+AG/GG” vs “TT+AA”: OR = 0.569, 95%CI = 0.395-0.821; “GT+AG/GG” vs “TT+AA”: OR = 0.318, 95%CI = 0.128-0.788, respectively). Stratification analysis revealed that the frequencies of the rs11249006 “AG/GG” genotypes in the subgroups of size ≤4.11 and IPSS ≤ 28 were significantly higher than those in the subgroups of size >4.11 and IPSS > 28. Therefore, the IL-28Rα gene polymorphism might be involved in the development of LUTS. © FUNPEC-RP.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2015]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学 4 区遗传学

最新[2023]版：

无

第一作者：

第一作者机构： [a]Department of Urology, The First People Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia (2021 Edition) [2]小体积前列腺增生症的诊治(附45例报告) [3]Association of Single Nucleotide Polymorphism at rs2275294 in the ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis. [4]小体积前列腺增生症的诊治(附45例报告) [5]NINJ2基因多态性与云南汉族脑卒中患者的相关性研究 [6]脂联素基因启动子多态性与白族原发性高血压的相关性 [7]Association of Dopamine D1 and D3 Receptor Gene Polymorphisms with Essential Hypertension in 3 Ethnic Groups in China [8]Genetic effects of XRCC4 and ligase IV genes on human glioma [9]Association between COMT Polymorphism Val158Met and Opioid Consumption in Patients with Postoperative Pain: A Meta-Analysis [10]Study on the association between vitamin D receptor gene fokl (T/C) polymorphisms and the susceptibility to type 2 diabetic kidney disease of Han nationality in south of China