机构：[1]Department of Thyroid and Breast Surgery, The First People's Hospital of Yunnan Province (the Affiliated Kunhua Hospital of Kunming University of Science and Technology), Kunming, China.外科片乳腺甲状腺外科云南省第一人民医院[2]Department of Thyroid and Breast Surgery, The People's Armed Police Hospital of Yunnan Province, Kunming, China.[3]Department of Surgery Four, The Second People's Hospital of Baoshan City, Baoshan, China.
Background:
Tumor-infiltrating lymphocytes have been reported to be associated with response to neoadjuvant chemotherapy and survival in breast cancer (BC) patients. However, little is known about the value of peripheral blood parameter in predicting the prognosis in BC.
Methods:
In this study, parameters of complete blood count from 417 BC patients with a median 7.6-year follow-up after surgery were collected and correlated with patient survival.
Results:
It was found that leukocyte counts were positively correlated with disease-free survival (DFS, p = 0.016) and overall survival (OS, p = 0.014), whereas platelet counts were negatively correlated with DFS (p = 0.003) and OS (p = 0.082) in BC. Leukocyte and platelet counts were independent prognostic factors for the BC patient survival. Besides, the prognostic value of leukocyte and platelet counts was further evaluated in the BC patients with different molecular subtypes. Together, BC patients with high leukocyte counts and low platelet counts had better DFS (p = 0.001) and OS (p = 0.017) than the other patients.
Conclusion:
Parameters of complete blood count could be acquired easily and serve as cost-effective prognostic biomarkers in BC.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学4 区药学4 区核医学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学4 区药学4 区核医学
JCR分区：
出版当年[2019]版：
Q3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3PHARMACOLOGY & PHARMACYQ3MEDICINE, RESEARCH & EXPERIMENTALQ3ONCOLOGY
最新[2023]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3MEDICINE, RESEARCH & EXPERIMENTALQ3ONCOLOGYQ3PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Thyroid and Breast Surgery, The First People's Hospital of Yunnan Province (the Affiliated Kunhua Hospital of Kunming University of Science and Technology), Kunming, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Thyroid and Breast Surgery, The First People's Hospital of Yunnan Province (the Affiliated Kunhua Hospital of Kunming University of Science and Technology), Kunming, China.[*1]Department of Thyroid and Breast Surgery, The First People’s Hospital of Yunnan Province(the Affiliated Kunhua Hospital of Kunming University of Science and Technology) ,157 Jinbi Road Xishan District, Kunming 650100, China
推荐引用方式(GB/T 7714)：
Li Li,Wang Jianjun,Meng Shaoda,et al.Peripheral Blood Leukocytes and Platelets Serve as Prognostic Factors in Breast Cancer.[J].Cancer biotherapy & radiopharmaceuticals.2020,doi:10.1089/cbr.2019.3032.
APA：
Li Li,Wang Jianjun,Meng Shaoda,Li Zhongquan,Huang Zhenfan...&Yang Kunxian.(2020).Peripheral Blood Leukocytes and Platelets Serve as Prognostic Factors in Breast Cancer..Cancer biotherapy & radiopharmaceuticals,,
MLA：
Li Li,et al."Peripheral Blood Leukocytes and Platelets Serve as Prognostic Factors in Breast Cancer.".Cancer biotherapy & radiopharmaceuticals .(2020)
