机构：[1]Department of Endocrinology and Metabolism and the institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China, 110001[2]Department of Endocrinology, Chinese PLA General Hospital, Beijing, P.R. China, 100853[3]Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China, 400038[4]Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, P.R. China, 116011大连医科大学附属第一医院[5]Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, Ningxia, P.R. China, 750004[6]Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, P.R. China, 330006[7]Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China, 150001[8]Department of Endocrinology, Hohhot First Hospital, Hohhot, Inner Mongolia, P.R. China, 010000[9]Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China, 410011[10]Research center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, P.R. China, 210028[11]Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China, 350001[12]Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, P.R. China, 450052[13]Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P.R. China, 530021[14]Department of Endocrinology, Hainan General Hospital, Haikou, Hainan, P.R. China, 570311[15]Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shannxi, P.R. China, 710061[16]Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China, 430022华中科技大学同济医学院附属协和医院[17]Department of Endocrinology, the First Hospital of Lanzhou University, Lanzhou, Gansu, P.R. China, 730000[18]Department of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, 610041四川大学华西医院[19]Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, P.R. China, 130021[20]Department of Endocrinology, Shanghai University of Medicine & Health Science Affiliated Zhoupu Hosipital, Shanghai, P.R. China, 201318[21]Department of Endocrinology, The First Hospital of An Hui Medical University, Hefei, Anhui, P.R. China, 230000[22]Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, P.R. China, 650032内科片内分泌科云南省第一人民医院[23]Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China, 510120中山大学附属第二医院[24]Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, P.R. China, 030001[25]Department of Endocrinology and Metabolism, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, P.R. China, 850000[26]Department of Endocrinology, Qinghai Provincial People's Hospital, Xining, Qinghai, P.R. China, 810000[27]Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R. China, 310051[28]Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou, P.R. China, 550004[29]Department of Endocrinology, Second hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China, 050000[30]Department of Endocrinology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P.R. China, 830054[31]Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, P.R. China, 300052.
Malnutrition in early life may permanently change the structure and function of the body, which lead to a number of diseases in adulthood. The effect of famine exposure during the early life on thyroid function and disorders remains unclear. This study investigated the association between exposure to the Great Chinese Famine (1959-1961) in early life and thyroid function and disorders in adulthood.
9881 subjects with appropriate birth dates derived from the Thyroid disorders, Iodine status and Diabetes Epidemiological survey were included. Thyroid function and disorders were defined by the test results of blood sample and ultrasonography of all participants. Associations between famine exposure in early life and thyroid function and disorders in adulthood were assessed with binary logistic regression and linear regression.
Participants exposed to the Great Chinese Famine during the fetal stage was associated with a higher TSH level in adulthood (β = 0.024; P = 0.038), compared with the non-exposed participants. The association was significant among rural participants (β = 0.039; P = 0.02) but not in urban participants (β = 0.005; P =0.77). Fetal-exposed group did not show a higher risk of thyroid disorders than the age-balanced control group, including overt hyperthyroidism, subclinical hyperthyroidism, overt hypothyroidism, subclinical hypothyroidism, autoimmune thyroiditis, and thyroid nodules (P > 0.05).
Famine exposure during the fetal stage was associated with a higher TSH level in adulthood. The fetal stage could be the critical period for programming the pituitary-thyroid axis.
基金：
Research Fund for Public Welfare from National Health and Family Planning Commission of China [201402005]
第一作者机构：[1]Department of Endocrinology and Metabolism and the institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China, 110001
共同第一作者：
通讯作者：
通讯机构：[1]Department of Endocrinology and Metabolism and the institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China, 110001[*1]Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155, Nanjing Bei street, Shenyang, P.R. China, 110001.[*2]The institute of Endocrinology ,The First Hospital of China Medical University, No. 155, Nanjing Bei street, Shenyang, P.R. China, 110001.
推荐引用方式(GB/T 7714)：
Jiahui Guo,Di Teng,Xiaoguang Shi,et al.Exposure to the Chinese Great Famine in early life and thyroid function and disorders in adulthood: a cross-sectional study.[J].THYROID.2021,31(4):563-571.doi:10.1089/thy.2020.0325.
APA：
Jiahui Guo,Di Teng,Xiaoguang Shi,Yongze Li,Jianming Ba...&Weiping Teng.(2021).Exposure to the Chinese Great Famine in early life and thyroid function and disorders in adulthood: a cross-sectional study..THYROID,31,(4)
MLA：
Jiahui Guo,et al."Exposure to the Chinese Great Famine in early life and thyroid function and disorders in adulthood: a cross-sectional study.".THYROID 31..4(2021):563-571
医学