资源类型：
期刊
WOS体系：
Article
Pubmed体系：
Journal Article
收录情况：
◇ SCIE
文章类型：
论著
机构：
[1]Department of Urinary Surgery, Qujing No. 1 People's Hospital, Qujing, Yunnan 655000, China
[2]Orthopedics Department of Joint Trauma, Yidu Central Hospital of Weifang, Weifang, Shandong 261000, China
[3]Department of Cardiothoracic Surgery, Jining First People's Hospital, Jining, Shandong 272000, China
[4]Department of Urology Surgery, Jining First People's Hospital, Jining, Shandong 272000, China
ISSN：
0024-3205
关键词：
ELK1
SNHG7
miR-2682-5p
Bladder cancer
摘要：
The purpose of this paper is to unearth the ceRNA regulatory mechanism of SNHG7 in bladder cancer (BCa).
The expression of SNHG7 in BCa cells was uncovered by qRT-PCR. The biological functions of SNHG7 in BCa cells were explored by CCK-8 assay, colony formation assay, flow cytometry analysis, wound healing assay and transwell assay. Luciferase reporter assay and RIP assay were applied to analyze the interaction of ELK1 with SNHG7 or miR-2682-5p.
SNHG7 was conspicuously highly expressed in BCa tissues and cells. The upregulated expression of SNHG7 was related with poor prognosis in BCa patients. Moreover, SNHG7 exerted oncogenic functions in BCa through enhancing cell growth, migration and invasion. ELK1 increased the level of SNHG7 by binding with the promoter region of SNHG7. SNHG7 strengthened the expression of ELK1 via acting as a sponge of miR-2682-5p. Both ELK1 and miR-2682-5p involved in the SNHG7-mediated BCa progression.
ELK1/SNHG7/miR-2682-5p feedback loop enhances cell growth, migration and invasion in BCa.
Copyright © 2020. Published by Elsevier Inc.
被引次数：
23
WOS：
WOS:000593979600003
PubmedID：
32898531
中科院(CAS)分区：
出版当年[2020]版：
大类
|
3 区
医学
小类
|
3 区
医学：研究与实验
3 区
药学
最新[2025]版：
大类
|
3 区
医学
小类
|
2 区
药学
3 区
医学：研究与实验
JCR分区：
出版当年[2019]版：
Q2
MEDICINE, RESEARCH & EXPERIMENTAL
Q2
PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1
MEDICINE, RESEARCH & EXPERIMENTAL
Q1
PHARMACOLOGY & PHARMACY
影响因子：
5.2
最新[2023版]
5.3
最新五年平均
3.647
出版当年[2019版]
3.413
出版当年五年平均
3.448
出版前一年[2018版]
5.037
出版后一年[2020版]
第一作者：
Wang Weisheng
第一作者机构：
[1]Department of Urinary Surgery, Qujing No. 1 People's Hospital, Qujing, Yunnan 655000, China
[*1]Department of Urinary Surgery, Qujing No. 1 People’s Hospital, Qujing, Yunnan, 655000, China.
通讯作者：
Wang Weisheng
通讯机构：
[1]Department of Urinary Surgery, Qujing No. 1 People's Hospital, Qujing, Yunnan 655000, China
[*1]Department of Urinary Surgery, Qujing No. 1 People’s Hospital, Qujing, Yunnan, 655000, China.
推荐引用方式(GB/T 7714)：
Wang Weisheng,Chen Shixia,Song Xuejing,et al.ELK1/lncRNA-SNHG7/miR-2682-5p feedback loop enhances bladder cancer cell growth.[J].LIFE SCIENCES.2020,262:doi:10.1016/j.lfs.2020.118386.
APA：
Wang Weisheng,Chen Shixia,Song Xuejing,Gui Junqing,Li Yong&Li Mianzhou.(2020).ELK1/lncRNA-SNHG7/miR-2682-5p feedback loop enhances bladder cancer cell growth..LIFE SCIENCES,262,
MLA：
Wang Weisheng,et al."ELK1/lncRNA-SNHG7/miR-2682-5p feedback loop enhances bladder cancer cell growth.".LIFE SCIENCES 262.(2020)
