机构：[1]School of Stomatology and Medicine, Foshan University,[2]Pathology and Clinical Laboratories, First People’s Hospital of Foshan, Foshan,[3]Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong,[4]Department of Pathology, Xianning Central Hospital, Xianning, Hubei[5]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Immune cells have an uncertain function during the progression of extranodal natural killer/T-cell lymphoma (ENKTL). The present study determined the distribution, phenotype, and clinical significance of B lymphocytes in ENKTL. Immunohistochemistry indicated high infiltration of CD20(+)B lymphocytes in the tumour tissues of 40% of the patients, and that a high infiltration correlated with better overall survival. Moreover, B lymphocytes had an active mature phenotypein situand suppressed the proliferation of ENKTL cellsin vitro. These results suggest that tumour infiltration of CD20(+)B lymphocytes may be a new prognostic indicator for patients with ENKTL.
基金：
The present study was funded by National key research and
development program of China (No. 2018YFA0902702), The
National Science and Technology Major Project of China (No.
2018ZX10731301-003-007), National Natural Science Foundation
of China (No. 81801558, No. 81870307, No. 81901881),
The University Special Innovative Research Program of
Department of Education of Guangdong Province (No.2017KQNCX210, No. 2017KTSCX189) and Foshan Science
and Technology Innovation Project (No. 1920001000958).
第一作者机构：[1]School of Stomatology and Medicine, Foshan University,
通讯作者：
通讯机构：[1]School of Stomatology and Medicine, Foshan University,[2]Pathology and Clinical Laboratories, First People’s Hospital of Foshan, Foshan,[*1]School of Stomatology and Medicine, Foshan University, Foshan 528000, Guangdong, China.[*2]Department of Pathology, The First People’s Hospital of Foshan, Foshan 528000, Guangdong, China.
推荐引用方式(GB/T 7714)：
Chen Min-Min,Zeng Guo-Peng,Li Jing,et al.High infiltration of CD20(+)B lymphocytes in extranodal natural killer/T-cell lymphoma is associated with better prognosis[J].BRITISH JOURNAL OF HAEMATOLOGY.2020,doi:10.1111/bjh.17069.
APA：
Chen, Min-Min,Zeng, Guo-Peng,Li, Jing,Fu, Jun-Hong,Long, Ya-Yi...&Liu, Fang.(2020).High infiltration of CD20(+)B lymphocytes in extranodal natural killer/T-cell lymphoma is associated with better prognosis.BRITISH JOURNAL OF HAEMATOLOGY,,
MLA：
Chen, Min-Min,et al."High infiltration of CD20(+)B lymphocytes in extranodal natural killer/T-cell lymphoma is associated with better prognosis".BRITISH JOURNAL OF HAEMATOLOGY .(2020)
医学