机构:[1]Department of Hematology, National Key Clinical Specialty of Hematology, Yunnan Blood Disease Clinical Medical Center, Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China,内科片血液内科云南省第一人民医院[2]Kunming University of Science and Technology, Kunming, China
Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) microenvironment. Several cell types that regulate HSC niche have been identified, including both non-hematopoietic cells and HSC-derived cells. Specific changes in the niche composition can result in hematological malignancies. Furthermore, processes such as homing, proliferation, and differentiation of HSCs are strongly controlled by the BM niche and have been reported to be related to the success of hematopoietic stem cell transplantation (HSCT). Single-cell sequencing and in vivo imaging are powerful techniques to study BM microenvironment in hematological malignancies and after HSCT. In this review, we discuss how different components of the BM niche, particularly non-hematopoietic and hematopoietic cells, regulate normal hematopoiesis, and changes in the BM niche in leukemia and after HSCT. We believe that this comprehensive review will provide clues for further research on improving HSCT efficiency and exploring potential therapeutic targets for leukemia.
基金:
This work was supported by the National Natural Science
Foundation of China (82070173, 81700164, and 82060810),
the Yunnan Applied Basic Research Projects Foundation
(2018FB112), the Medical Reserve Talents Cultivation
Project of Yunnan Province (H2017012), the Science and
Technology Department of Yunnan Province-Kunming
Medical University Applied Basic Research Joint Special
Fund Young Doctor Project [2018FE001(-156)], the Doctor
Research Fund of Yunnan First People’s Hospital (KHBS-
2020-007), the Open Project of Yunnan Blood Clinical
Medical Center (2019LCZXKF-XY02, 2019LCZXKF-XY14
and 2019LCZXKF-XY11).
第一作者机构:[1]Department of Hematology, National Key Clinical Specialty of Hematology, Yunnan Blood Disease Clinical Medical Center, Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China,[2]Kunming University of Science and Technology, Kunming, China
通讯作者:
通讯机构:[1]Department of Hematology, National Key Clinical Specialty of Hematology, Yunnan Blood Disease Clinical Medical Center, Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China,[2]Kunming University of Science and Technology, Kunming, China
推荐引用方式(GB/T 7714):
Man Yan,Yao Xiangmei,Yang Tonghua,et al.Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation[J].FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.2021,9:doi:10.3389/fcell.2021.621214.
APA:
Man, Yan,Yao, Xiangmei,Yang, Tonghua&Wang, Yajie.(2021).Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9,
MLA:
Man, Yan,et al."Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9.(2021)