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Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation

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机构: [1]Department of Hematology, National Key Clinical Specialty of Hematology, Yunnan Blood Disease Clinical Medical Center, Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China, [2]Kunming University of Science and Technology, Kunming, China
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关键词: hematopoietic stem cells hematopoietic stem cell niche niche cells hematologic malignancy hematopoietic stem cell transplantation

摘要:
Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) microenvironment. Several cell types that regulate HSC niche have been identified, including both non-hematopoietic cells and HSC-derived cells. Specific changes in the niche composition can result in hematological malignancies. Furthermore, processes such as homing, proliferation, and differentiation of HSCs are strongly controlled by the BM niche and have been reported to be related to the success of hematopoietic stem cell transplantation (HSCT). Single-cell sequencing and in vivo imaging are powerful techniques to study BM microenvironment in hematological malignancies and after HSCT. In this review, we discuss how different components of the BM niche, particularly non-hematopoietic and hematopoietic cells, regulate normal hematopoiesis, and changes in the BM niche in leukemia and after HSCT. We believe that this comprehensive review will provide clues for further research on improving HSCT efficiency and exploring potential therapeutic targets for leukemia.

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出版当年[2021]版:
大类 | 2 区 生物
小类 | 2 区 发育生物学 3 区 细胞生物学
最新[2025]版:
大类 | 2 区 生物学
小类 | 2 区 发育生物学 3 区 细胞生物学
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出版当年[2020]版:
Q1 DEVELOPMENTAL BIOLOGY Q2 CELL BIOLOGY
最新[2024]版:
Q1 DEVELOPMENTAL BIOLOGY Q2 CELL BIOLOGY

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第一作者机构: [1]Department of Hematology, National Key Clinical Specialty of Hematology, Yunnan Blood Disease Clinical Medical Center, Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China, [2]Kunming University of Science and Technology, Kunming, China
通讯作者:
通讯机构: [1]Department of Hematology, National Key Clinical Specialty of Hematology, Yunnan Blood Disease Clinical Medical Center, Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China, [2]Kunming University of Science and Technology, Kunming, China
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