Enhancer RNAs, a type of long non-coding RNAs (lncRNAs), play a critical role in the occurrence and development of glioma. RNA-seq data from 161 glioblastoma multiforme (GBM) samples were acquired from The Cancer Genome Atlas database. Then, 70 eRNAs were identified as prognosis-related genes, which had significant relations with overall survival (log-rank test, p < 0.05). AC003092.1 was demonstrated as an immune-related eRNA by functional enrichment analysis. We divided samples into two groups based on AC003092.1 expression: AC003092.1 High (AC003092.1_H) and AC003092.1 Low (AC003092.1_L) and systematically analyzed the influence of AC003092.1 on the immune microenvironment by single-sample gene-set enrichment analysis and CIBERSORTx. We quantified AC003092.1 and TFPI2 levels in 11 high-grade gliomas, 5 low-grade gliomas, and 7 GBM cell lines. Our study indicates that AC003092.1 is related to glioma-immunosuppressive microenvironment, and these results offer innovative sights into GBM immune therapy.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872324]; Guangdong Basic and Applied Basic Research Foundation [2020A1515110203]; Fundamental Research Funds for Junior Teachers in Sun Yat-sen University, China [20ykpy163]; Science and Technology Program of Guangzhou, China [201704020133]; Science and Technology Program of Jiangmen, China [2018630100110019805]; Medical Scientific Research Foundation of Guangdong Province of China [A2020149]; Science and Technology Planning Project of Guangdong Province, China [2015B010125003]
第一作者机构：[1]Sun Yat Sen Univ Canc, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Dept Neurosurg Neurooncol, Guangzhou, Peoples R China
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推荐引用方式(GB/T 7714)：
Guo Xiao-Yu,Zhong Sheng,Wang Zhen-Ning,et al.Immunogenomic Profiling Demonstrate AC003092.1 as an Immune-Related eRNA in Glioblastoma Multiforme[J].FRONTIERS IN GENETICS.2021,12:doi:10.3389/fgene.2021.633812.
APA：
Guo, Xiao-Yu,Zhong, Sheng,Wang, Zhen-Ning,Xie, Tian,Duan, Hao...&Mou, Yong-Gao.(2021).Immunogenomic Profiling Demonstrate AC003092.1 as an Immune-Related eRNA in Glioblastoma Multiforme.FRONTIERS IN GENETICS,12,
MLA：
Guo, Xiao-Yu,et al."Immunogenomic Profiling Demonstrate AC003092.1 as an Immune-Related eRNA in Glioblastoma Multiforme".FRONTIERS IN GENETICS 12.(2021)
