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Prognostic Model Construction and Immune Microenvironment Analysis of Breast Cancer Based on Ferroptosis-Related lncRNAs.

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收录情况： ◇ SCIE

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机构： [1]Institute of Plastic Surgery, Weifang Medical College, Weifang, Shandong, People's Republic of China. [2]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China. [3]Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, People's Republic of China.

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关键词： breast cancer ferroptosis immune microenvironment lncRNA

摘要：

To construct a prognostic model of breast cancer using ferroptosis-related lncRNAs and explore novel therapeutic targets.A prognostic characteristic model based on differential expression of ferroptosis-related lncRNAs in breast cancer was established based on TCGA data.Eleven ferroptosis-related lncRNAs associated with breast cancer prognosis were identified. Kaplan-Meier analysis suggested that high-risk lncRNA signatures correspond to a poor prognosis. The AUC of the signature lncRNAs was 0.682, demonstrating that it is accurate in predicting BC prognosis. GSEA showed that ferroptosis-related lncRNAs in high-risk individuals are mainly enriched in cell cycle, cell adhesion and tumor pathways. Immunity and gene expression analysis revealed that APC co-inhibition, check-point, HLA, inflammation-promoting and T cell co-stimulation among others were significantly different between the high-and low-risk group. Three immune checkpoints were highly expressed in the high-risk group.Ferroptosis-related lncRNAs can be used as a prognostic feature to construct a prognostic model of breast cancer, based on which early detection markers, therapeutic targets and anti-tumor immune microenvironment can be studied, and clinical treatment can also be instructive.© 2021 Jia et al.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区医学：内科

最新[2023]版：

大类 | 4 区医学

小类 | 3 区医学：内科

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出版当年[2020]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q2 MEDICINE, GENERAL & INTERNAL

影响因子： 2.1 最新[2023版] 2.2 最新五年平均 2.466 出版当年[2020版] 2.724 出版当年五年平均 1.927 出版前一年[2019版] 2.145 出版后一年[2021版]

第一作者：

第一作者机构： [1]Institute of Plastic Surgery, Weifang Medical College, Weifang, Shandong, People's Republic of China.

通讯作者：

通讯机构： [2]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China. [*1]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, No. 295, Xi Chang Road, Kunming, Yunnan, 650032, People’s Republic of China

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