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PRUNE2 inhibits progression of colorectal cancer in vitro and in vivo.

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机构： [1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China. [2]Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China. [3]Department of Gastroenterology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China. [4]Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China. [5]Department of Gastroenterology, South China Hospital, Health Science Center, Shenzhen University, Shenzhen, Guangzhou 518116, P.R. China. [6]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.

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关键词： colorectal cancer prune homolog 2 with BCH domain proliferation invasion tumorigenicity

摘要：

Prune homolog 2 with BCH domain (PRUNE2) is associated with prostate cancer, neuroblastoma, glioblastoma and melanoma; however, the function of PRUNE2 in colorectal cancer (CRC) remains unknown. The present study aimed to evaluate the effects of PRUNE2 on the development of CRC. The biological function of PRUNE2 in CRC cell lines was investigated by using Cell Counting Kit-8, colony formation, flow cytometry and Transwell assay. Additionally, a mouse model was established to investigate the effect of PRUNE2 on metastasis of CRC cells. The expression levels of PRUNE2 were lower in CRC compared with adjacent normal tissue and this expression pattern was associated with poor relapse-free survival probability. PRUNE2 overexpression significantly decreased cell proliferation and invasion, increased cell apoptosis and arrested the cell cycle. Consistently, it increased the protein expression levels of pro-apoptosis genes and decreased the expression of antiapoptotic proteins. PRUNE2 knockdown had the opposite effects. Furthermore, PRUNE2 overexpression decreased the tumorigenicity of CRC cells. In conclusion, PRUNE2 decreased cell survival, proliferation, invasion and tumorigenicity and promoted apoptosis, suggesting that PRUNE2 may function as a tumor-suppressive gene in CRC.Copyright: © Li et al.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

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出版当年[2021]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.4 最新[2023版] 2.3 最新五年平均 2.751 出版当年[2021版] 2.475 出版当年五年平均 2.447 出版前一年[2020版] 2.7 出版后一年[2022版]

第一作者：

第一作者机构： [1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China. [2]Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China. [3]Department of Gastroenterology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China. [4]Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.

通讯作者：

通讯机构： [2]Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China. [3]Department of Gastroenterology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.

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PRUNE2 inhibits progression of colorectal cancer in vitro and in vivo.

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