Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD) that also belongs to the family of DNA- and RNA-binding proteins. YB-1 is present in both the nucleus and cytoplasm and plays versatile roles in gene transcription, RNA splicing, DNA damage repair, cell cycle progression, and immunity. Cumulative evidence suggests that YB-1 promotes the progression of multiple tumor types and serves as a potential tumor biomarker and therapeutic target. This review comprehensively summarizes the emerging functions, mechanisms, and regulation of YB-1 in cancers, and further discusses targeted strategies.
基金：
National Key R&D Program of China [2020YFA0112300, 2020YFA0803200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U2102203, 82173014, 81830087, 81872414]; CAS Light of West China program; Yunnan Fundamental Research Projects [202001AW070018, 202101AS070050, 2019FB112]; Reserve talents for Yunnan Province of Medical Science [H-2018078]
第一作者机构：[1]Kunming Univ Sci & Technol, Med Fac, Kunming 650504, Yunnan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650201, Yunnan, Peoples R China[5]Kunming Med Univ, Acad Biomed Engn, Kunming 650500, Yunnan, Peoples R China[6]Kunming Med Univ, Affiliated Hosp 3, Kunming 650118, Yunnan, Peoples R China
推荐引用方式(GB/T 7714)：
Yin Qiyan,Zheng Min,Luo Qianmei,et al.YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy[J].CELLS.2022,11(7):doi:10.3390/cells11071217.
APA：
Yin, Qiyan,Zheng, Min,Luo, Qianmei,Jiang, Dewei,Zhang, Huifeng&Chen, Ceshi.(2022).YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy.CELLS,11,(7)
MLA：
Yin, Qiyan,et al."YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy".CELLS 11..7(2022)
